Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption

Cubilin and the transmembrane protein amnionless (AMN) form the endocytic receptor cubam that is essential for intestinal vitamin B12 uptake. Here the authors present the 2.3 Å crystal structure of AMN in complex with the amino-terminal region of cubilin and discuss cubam architecture and disease ca...

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Main Authors:	Casper Larsen, Anders Etzerodt, Mette Madsen, Karsten Skjødt, Søren Kragh Moestrup, Christian Brix Folsted Andersen
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/80fcc40c89f8413ba5eb477b1dfa5777
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spelling	oai:doaj.org-article:80fcc40c89f8413ba5eb477b1dfa57772021-12-02T16:49:18ZStructural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption10.1038/s41467-018-07468-42041-1723https://doaj.org/article/80fcc40c89f8413ba5eb477b1dfa57772018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07468-4https://doaj.org/toc/2041-1723Cubilin and the transmembrane protein amnionless (AMN) form the endocytic receptor cubam that is essential for intestinal vitamin B12 uptake. Here the authors present the 2.3 Å crystal structure of AMN in complex with the amino-terminal region of cubilin and discuss cubam architecture and disease causing mutations.Casper LarsenAnders EtzerodtMette MadsenKarsten SkjødtSøren Kragh MoestrupChristian Brix Folsted AndersenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Casper Larsen Anders Etzerodt Mette Madsen Karsten Skjødt Søren Kragh Moestrup Christian Brix Folsted Andersen Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption
description	Cubilin and the transmembrane protein amnionless (AMN) form the endocytic receptor cubam that is essential for intestinal vitamin B12 uptake. Here the authors present the 2.3 Å crystal structure of AMN in complex with the amino-terminal region of cubilin and discuss cubam architecture and disease causing mutations.
format	article
author	Casper Larsen Anders Etzerodt Mette Madsen Karsten Skjødt Søren Kragh Moestrup Christian Brix Folsted Andersen
author_facet	Casper Larsen Anders Etzerodt Mette Madsen Karsten Skjødt Søren Kragh Moestrup Christian Brix Folsted Andersen
author_sort	Casper Larsen
title	Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption
title_short	Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption
title_full	Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption
title_fullStr	Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption
title_full_unstemmed	Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption
title_sort	structural assembly of the megadalton-sized receptor for intestinal vitamin b12 uptake and kidney protein reabsorption
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/80fcc40c89f8413ba5eb477b1dfa5777
work_keys_str_mv	AT casperlarsen structuralassemblyofthemegadaltonsizedreceptorforintestinalvitaminb12uptakeandkidneyproteinreabsorption AT andersetzerodt structuralassemblyofthemegadaltonsizedreceptorforintestinalvitaminb12uptakeandkidneyproteinreabsorption AT mettemadsen structuralassemblyofthemegadaltonsizedreceptorforintestinalvitaminb12uptakeandkidneyproteinreabsorption AT karstenskjødt structuralassemblyofthemegadaltonsizedreceptorforintestinalvitaminb12uptakeandkidneyproteinreabsorption AT sørenkraghmoestrup structuralassemblyofthemegadaltonsizedreceptorforintestinalvitaminb12uptakeandkidneyproteinreabsorption AT christianbrixfolstedandersen structuralassemblyofthemegadaltonsizedreceptorforintestinalvitaminb12uptakeandkidneyproteinreabsorption
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Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption

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