<named-content content-type="genus-species">Bifidobacterium longum</named-content> R0175 Protects Rats against <sc>d</sc>-Galactosamine-Induced Acute Liver Failure

ABSTRACT Acute liver failure is a severe liver disorder that poses considerable global challenges. Previous studies on Bifidobacterium longum R0175 have mainly focused on its psychotropic functions. The current research focused on the protective efficacy of B. longum R0175 against acute liver failur...

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Autores principales:	Kaicen Wang, Longxian Lv, Ren Yan, Qiangqiang Wang, Huiyong Jiang, Wenrui Wu, Yating Li, Jianzhong Ye, Jingjing Wu, Liya Yang, Xiaoyuan Bian, Xianwan Jiang, Yanmeng Lu, Jiaojiao Xie, Qing Wang, Jian Shen, Lanjuan Li
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Bifidobacterium longum R0175 acute liver failure metabolome microbiome probiotic Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/80fdff2c9f0847098602edeba604bc3f
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spelling	oai:doaj.org-article:80fdff2c9f0847098602edeba604bc3f2021-11-15T15:27:52Z<named-content content-type="genus-species">Bifidobacterium longum</named-content> R0175 Protects Rats against <sc>d</sc>-Galactosamine-Induced Acute Liver Failure10.1128/mSphere.00791-192379-5042https://doaj.org/article/80fdff2c9f0847098602edeba604bc3f2020-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00791-19https://doaj.org/toc/2379-5042ABSTRACT Acute liver failure is a severe liver disorder that poses considerable global challenges. Previous studies on Bifidobacterium longum R0175 have mainly focused on its psychotropic functions. The current research focused on the protective efficacy of B. longum R0175 against acute liver failure caused by d-galactosamine (d-GalN) in rats and further tested the hypothesis that B. longum R0175 exerted liver-protective effects by affecting the intestinal microbiota and fecal metabolites and by inhibiting inflammation. We found that oral gavage of B. longum R0175 markedly reduced the severity of liver injury in d-GalN-treated rats, as evidenced by decreased serum levels of aspartate aminotransferase (AST) and total bile acids (TBAs) (P < 0.05). Moreover, the plasma concentrations of proinflammatory cytokines (interleukin 1β [IL-1β] and tumor necrosis factor-α [TNF-α]) and chemokines (granulocyte-macrophage colony-stimulating factor [GM-CSF], macrophage chemoattractant protein 1 [MCP-1], chemokine [C-X-C motif] ligand 1 [CXCL1], chemokine [C-C motif] ligand 5 [CCL5], and macrophage inflammatory protein-1α [MIP-1α]) were also markedly reduced (P < 0.05). Pretreatment with B. longum R0175 partially reversed the gut microbiota dysbiosis in rats with liver injury by increasing the relative abundances of potentially beneficial bacteria, such as Alloprevotella spp., and decreasing the relative abundances of potentially harmful bacteria, such as Acetatifactor muris, Butyricimonas spp., and Oscillibacter spp. Furthermore, B. longum R0175 administration partially improved the metabolic function of the intestinal microbes, as indicated by the decreased level of lithocholic acid found in the feces. IMPORTANCE Our research investigated the protective and preventive roles of B. longum R0175 in a rat model of acute liver failure. The results illustrated that this probiotic strain exhibited protective effects in rats with acute liver failure. Thus, B. longum R0175 showed clinical application prospects that required further exploration.Kaicen WangLongxian LvRen YanQiangqiang WangHuiyong JiangWenrui WuYating LiJianzhong YeJingjing WuLiya YangXiaoyuan BianXianwan JiangYanmeng LuJiaojiao XieQing WangJian ShenLanjuan LiAmerican Society for MicrobiologyarticleBifidobacterium longum R0175acute liver failuremetabolomemicrobiomeprobioticMicrobiologyQR1-502ENmSphere, Vol 5, Iss 1 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bifidobacterium longum R0175 acute liver failure metabolome microbiome probiotic Microbiology QR1-502
spellingShingle	Bifidobacterium longum R0175 acute liver failure metabolome microbiome probiotic Microbiology QR1-502 Kaicen Wang Longxian Lv Ren Yan Qiangqiang Wang Huiyong Jiang Wenrui Wu Yating Li Jianzhong Ye Jingjing Wu Liya Yang Xiaoyuan Bian Xianwan Jiang Yanmeng Lu Jiaojiao Xie Qing Wang Jian Shen Lanjuan Li <named-content content-type="genus-species">Bifidobacterium longum</named-content> R0175 Protects Rats against <sc>d</sc>-Galactosamine-Induced Acute Liver Failure
description	ABSTRACT Acute liver failure is a severe liver disorder that poses considerable global challenges. Previous studies on Bifidobacterium longum R0175 have mainly focused on its psychotropic functions. The current research focused on the protective efficacy of B. longum R0175 against acute liver failure caused by d-galactosamine (d-GalN) in rats and further tested the hypothesis that B. longum R0175 exerted liver-protective effects by affecting the intestinal microbiota and fecal metabolites and by inhibiting inflammation. We found that oral gavage of B. longum R0175 markedly reduced the severity of liver injury in d-GalN-treated rats, as evidenced by decreased serum levels of aspartate aminotransferase (AST) and total bile acids (TBAs) (P < 0.05). Moreover, the plasma concentrations of proinflammatory cytokines (interleukin 1β [IL-1β] and tumor necrosis factor-α [TNF-α]) and chemokines (granulocyte-macrophage colony-stimulating factor [GM-CSF], macrophage chemoattractant protein 1 [MCP-1], chemokine [C-X-C motif] ligand 1 [CXCL1], chemokine [C-C motif] ligand 5 [CCL5], and macrophage inflammatory protein-1α [MIP-1α]) were also markedly reduced (P < 0.05). Pretreatment with B. longum R0175 partially reversed the gut microbiota dysbiosis in rats with liver injury by increasing the relative abundances of potentially beneficial bacteria, such as Alloprevotella spp., and decreasing the relative abundances of potentially harmful bacteria, such as Acetatifactor muris, Butyricimonas spp., and Oscillibacter spp. Furthermore, B. longum R0175 administration partially improved the metabolic function of the intestinal microbes, as indicated by the decreased level of lithocholic acid found in the feces. IMPORTANCE Our research investigated the protective and preventive roles of B. longum R0175 in a rat model of acute liver failure. The results illustrated that this probiotic strain exhibited protective effects in rats with acute liver failure. Thus, B. longum R0175 showed clinical application prospects that required further exploration.
format	article
author	Kaicen Wang Longxian Lv Ren Yan Qiangqiang Wang Huiyong Jiang Wenrui Wu Yating Li Jianzhong Ye Jingjing Wu Liya Yang Xiaoyuan Bian Xianwan Jiang Yanmeng Lu Jiaojiao Xie Qing Wang Jian Shen Lanjuan Li
author_facet	Kaicen Wang Longxian Lv Ren Yan Qiangqiang Wang Huiyong Jiang Wenrui Wu Yating Li Jianzhong Ye Jingjing Wu Liya Yang Xiaoyuan Bian Xianwan Jiang Yanmeng Lu Jiaojiao Xie Qing Wang Jian Shen Lanjuan Li
author_sort	Kaicen Wang
title	<named-content content-type="genus-species">Bifidobacterium longum</named-content> R0175 Protects Rats against <sc>d</sc>-Galactosamine-Induced Acute Liver Failure
title_short	<named-content content-type="genus-species">Bifidobacterium longum</named-content> R0175 Protects Rats against <sc>d</sc>-Galactosamine-Induced Acute Liver Failure
title_full	<named-content content-type="genus-species">Bifidobacterium longum</named-content> R0175 Protects Rats against <sc>d</sc>-Galactosamine-Induced Acute Liver Failure
title_fullStr	<named-content content-type="genus-species">Bifidobacterium longum</named-content> R0175 Protects Rats against <sc>d</sc>-Galactosamine-Induced Acute Liver Failure
title_full_unstemmed	<named-content content-type="genus-species">Bifidobacterium longum</named-content> R0175 Protects Rats against <sc>d</sc>-Galactosamine-Induced Acute Liver Failure
title_sort	<named-content content-type="genus-species">bifidobacterium longum</named-content> r0175 protects rats against <sc>d</sc>-galactosamine-induced acute liver failure
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/80fdff2c9f0847098602edeba604bc3f
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<named-content content-type="genus-species">Bifidobacterium longum</named-content> R0175 Protects Rats against <sc>d</sc>-Galactosamine-Induced Acute Liver Failure

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