ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test

Since the animal test ban on cosmetics in the EU in 2013, alternative in vitro safety tests have been actively researched to replace in vivo animal tests. For the development and evaluation of a new test method, reference chemicals with quality in vivo data are essential to assess the predictive cap...

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Autores principales:	Juhee Han, Ga-Young Lee, Green Bae, Mi-Jeong Kang, Kyung-Min Lim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	skin irritation test reference chemical alternative test method chemical database Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/80ffed2e6910469e901b732192c510be
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spelling	oai:doaj.org-article:80ffed2e6910469e901b732192c510be2021-11-25T19:08:21ZChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test10.3390/toxics91103142305-6304https://doaj.org/article/80ffed2e6910469e901b732192c510be2021-11-01T00:00:00Zhttps://www.mdpi.com/2305-6304/9/11/314https://doaj.org/toc/2305-6304Since the animal test ban on cosmetics in the EU in 2013, alternative in vitro safety tests have been actively researched to replace in vivo animal tests. For the development and evaluation of a new test method, reference chemicals with quality in vivo data are essential to assess the predictive capacity and applicability domain. Here, we compiled a reference chemical database (ChemSkin DB) for the development and evaluation of new in vitro skin irritation tests. The first candidates were selected from 317 chemicals (source data <i>n</i> = 1567) searched from the literature from the last 20 years, including previous validation study reports, ECETOC, and published papers. Chemicals showing inconsistent classification or those that were commercially unavailable, difficult or dangerous to handle, prohibitively expensive, or without quality in vivo or in vitro data were removed, leaving a total of 100 chemicals. Supporting references, in vivo Draize scores, UN GHS/EU CLP classifications and commercial sources were compiled. Test results produced by the approved methods of OECD Test No. 439 were included and compared using the classification table, scatter plot, and Pearson correlation analysis to identify the false predictions and differences between in vitro skin irritation tests. These results may provide an insight into the future development of new in vitro skin irritation tests.Juhee HanGa-Young LeeGreen BaeMi-Jeong KangKyung-Min LimMDPI AGarticleskin irritation testreference chemicalalternative test methodchemical databaseChemical technologyTP1-1185ENToxics, Vol 9, Iss 314, p 314 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	skin irritation test reference chemical alternative test method chemical database Chemical technology TP1-1185
spellingShingle	skin irritation test reference chemical alternative test method chemical database Chemical technology TP1-1185 Juhee Han Ga-Young Lee Green Bae Mi-Jeong Kang Kyung-Min Lim ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test
description	Since the animal test ban on cosmetics in the EU in 2013, alternative in vitro safety tests have been actively researched to replace in vivo animal tests. For the development and evaluation of a new test method, reference chemicals with quality in vivo data are essential to assess the predictive capacity and applicability domain. Here, we compiled a reference chemical database (ChemSkin DB) for the development and evaluation of new in vitro skin irritation tests. The first candidates were selected from 317 chemicals (source data <i>n</i> = 1567) searched from the literature from the last 20 years, including previous validation study reports, ECETOC, and published papers. Chemicals showing inconsistent classification or those that were commercially unavailable, difficult or dangerous to handle, prohibitively expensive, or without quality in vivo or in vitro data were removed, leaving a total of 100 chemicals. Supporting references, in vivo Draize scores, UN GHS/EU CLP classifications and commercial sources were compiled. Test results produced by the approved methods of OECD Test No. 439 were included and compared using the classification table, scatter plot, and Pearson correlation analysis to identify the false predictions and differences between in vitro skin irritation tests. These results may provide an insight into the future development of new in vitro skin irritation tests.
format	article
author	Juhee Han Ga-Young Lee Green Bae Mi-Jeong Kang Kyung-Min Lim
author_facet	Juhee Han Ga-Young Lee Green Bae Mi-Jeong Kang Kyung-Min Lim
author_sort	Juhee Han
title	ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test
title_short	ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test
title_full	ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test
title_fullStr	ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test
title_full_unstemmed	ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test
title_sort	chemskin reference chemical database for the development of an in vitro skin irritation test
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/80ffed2e6910469e901b732192c510be
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ChemSkin Reference Chemical Database for the Development of an In Vitro Skin Irritation Test

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