Is the Pain Just Physical? The Role of Psychological Distress, Quality of Life, and Autistic Traits in Ehlers–Danlos Syndrome, an Internet-Based Survey in Italy

Background: Ehlers–Danlos syndromes (EDS) have been associated with psychological distress, comorbid psychiatric disorders, and worsening in quality of life (QoL). Among the neurodevelopmental disorders, autism spectrum disorders (ASD) have shown the highest rates of co-occurrence with EDS. The reas...

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Autores principales:	Matteo Rocchetti, Alessandra Bassotti, Jacopo Corradi, Stefano Damiani, Gianluigi Pasta, Salvatore Annunziata, Viviana Guerrieri, Mario Mosconi, Davide Gentilini, Natascia Brondino
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Ehler–Danlos autism anxiety depression quality of life pain Medicine R
Acceso en línea:	https://doaj.org/article/81000acf99744c48b0f29539f2a60da5
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spelling	oai:doaj.org-article:81000acf99744c48b0f29539f2a60da52021-11-25T17:44:27ZIs the Pain Just Physical? The Role of Psychological Distress, Quality of Life, and Autistic Traits in Ehlers–Danlos Syndrome, an Internet-Based Survey in Italy10.3390/healthcare91114722227-9032https://doaj.org/article/81000acf99744c48b0f29539f2a60da52021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9032/9/11/1472https://doaj.org/toc/2227-9032Background: Ehlers–Danlos syndromes (EDS) have been associated with psychological distress, comorbid psychiatric disorders, and worsening in quality of life (QoL). Among the neurodevelopmental disorders, autism spectrum disorders (ASD) have shown the highest rates of co-occurrence with EDS. The reasons for these associations are unknown and a possible role of pain in increasing the risk of psychiatric disorders in EDS has been suggested. However, a detailed picture of an Italian EDS sample is still lacking. Methods: We conducted a web-based survey in a third level center for the diagnosis of EDS in northern Italy, to investigate psychological distress, QoL, and the presence of autistic traits. Furthermore, we correlated the psychometric data with some clinical variables. Results: We observed a high rate of psychological distress with 91% of the responders at high risk of common mental disorders, low QoL, and high prevalence of autistic traits in EDS patients. Specifically, patients lacking a specific genetic test, diagnosed as suspects of EDS appeared to be at greater risk and reported worse psychological QoL. Pain was significantly associated with both psychological distress and worse QoL. Conclusions: Our findings support the need of further research and of a multi-disciplinary approach to EDS including psychological and psychiatric liaison.Matteo RocchettiAlessandra BassottiJacopo CorradiStefano DamianiGianluigi PastaSalvatore AnnunziataViviana GuerrieriMario MosconiDavide GentiliniNatascia BrondinoMDPI AGarticleEhler–Danlosautismanxietydepressionquality of lifepainMedicineRENHealthcare, Vol 9, Iss 1472, p 1472 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ehler–Danlos autism anxiety depression quality of life pain Medicine R
spellingShingle	Ehler–Danlos autism anxiety depression quality of life pain Medicine R Matteo Rocchetti Alessandra Bassotti Jacopo Corradi Stefano Damiani Gianluigi Pasta Salvatore Annunziata Viviana Guerrieri Mario Mosconi Davide Gentilini Natascia Brondino Is the Pain Just Physical? The Role of Psychological Distress, Quality of Life, and Autistic Traits in Ehlers–Danlos Syndrome, an Internet-Based Survey in Italy
description	Background: Ehlers–Danlos syndromes (EDS) have been associated with psychological distress, comorbid psychiatric disorders, and worsening in quality of life (QoL). Among the neurodevelopmental disorders, autism spectrum disorders (ASD) have shown the highest rates of co-occurrence with EDS. The reasons for these associations are unknown and a possible role of pain in increasing the risk of psychiatric disorders in EDS has been suggested. However, a detailed picture of an Italian EDS sample is still lacking. Methods: We conducted a web-based survey in a third level center for the diagnosis of EDS in northern Italy, to investigate psychological distress, QoL, and the presence of autistic traits. Furthermore, we correlated the psychometric data with some clinical variables. Results: We observed a high rate of psychological distress with 91% of the responders at high risk of common mental disorders, low QoL, and high prevalence of autistic traits in EDS patients. Specifically, patients lacking a specific genetic test, diagnosed as suspects of EDS appeared to be at greater risk and reported worse psychological QoL. Pain was significantly associated with both psychological distress and worse QoL. Conclusions: Our findings support the need of further research and of a multi-disciplinary approach to EDS including psychological and psychiatric liaison.
format	article
author	Matteo Rocchetti Alessandra Bassotti Jacopo Corradi Stefano Damiani Gianluigi Pasta Salvatore Annunziata Viviana Guerrieri Mario Mosconi Davide Gentilini Natascia Brondino
author_facet	Matteo Rocchetti Alessandra Bassotti Jacopo Corradi Stefano Damiani Gianluigi Pasta Salvatore Annunziata Viviana Guerrieri Mario Mosconi Davide Gentilini Natascia Brondino
author_sort	Matteo Rocchetti
title	Is the Pain Just Physical? The Role of Psychological Distress, Quality of Life, and Autistic Traits in Ehlers–Danlos Syndrome, an Internet-Based Survey in Italy
title_short	Is the Pain Just Physical? The Role of Psychological Distress, Quality of Life, and Autistic Traits in Ehlers–Danlos Syndrome, an Internet-Based Survey in Italy
title_full	Is the Pain Just Physical? The Role of Psychological Distress, Quality of Life, and Autistic Traits in Ehlers–Danlos Syndrome, an Internet-Based Survey in Italy
title_fullStr	Is the Pain Just Physical? The Role of Psychological Distress, Quality of Life, and Autistic Traits in Ehlers–Danlos Syndrome, an Internet-Based Survey in Italy
title_full_unstemmed	Is the Pain Just Physical? The Role of Psychological Distress, Quality of Life, and Autistic Traits in Ehlers–Danlos Syndrome, an Internet-Based Survey in Italy
title_sort	is the pain just physical? the role of psychological distress, quality of life, and autistic traits in ehlers–danlos syndrome, an internet-based survey in italy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/81000acf99744c48b0f29539f2a60da5
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Is the Pain Just Physical? The Role of Psychological Distress, Quality of Life, and Autistic Traits in Ehlers–Danlos Syndrome, an Internet-Based Survey in Italy

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