Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

Retroviral integrases catalyze the insertion of viral DNA into the host cell DNA and can use nucleosomes as substrates for integration. Here the authors present the 3.9 Å cryo-EM structure of prototype foamy virus integrase after strand transfer into nucleosomal DNA, which together with single-molec...

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Autores principales:	Marcus D. Wilson, Ludovic Renault, Daniel P. Maskell, Mohamed Ghoneim, Valerie E. Pye, Andrea Nans, David S. Rueda, Peter Cherepanov, Alessandro Costa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81003a4887374f70b3a53f31395ad7bb
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id	oai:doaj.org-article:81003a4887374f70b3a53f31395ad7bb
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spelling	oai:doaj.org-article:81003a4887374f70b3a53f31395ad7bb2021-12-02T17:01:55ZRetroviral integration into nucleosomes through DNA looping and sliding along the histone octamer10.1038/s41467-019-12007-w2041-1723https://doaj.org/article/81003a4887374f70b3a53f31395ad7bb2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12007-whttps://doaj.org/toc/2041-1723Retroviral integrases catalyze the insertion of viral DNA into the host cell DNA and can use nucleosomes as substrates for integration. Here the authors present the 3.9 Å cryo-EM structure of prototype foamy virus integrase after strand transfer into nucleosomal DNA, which together with single-molecule FRET measurements provides evidence for a DNA looping and sliding mechanism of integrases.Marcus D. WilsonLudovic RenaultDaniel P. MaskellMohamed GhoneimValerie E. PyeAndrea NansDavid S. RuedaPeter CherepanovAlessandro CostaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marcus D. Wilson Ludovic Renault Daniel P. Maskell Mohamed Ghoneim Valerie E. Pye Andrea Nans David S. Rueda Peter Cherepanov Alessandro Costa Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer
description	Retroviral integrases catalyze the insertion of viral DNA into the host cell DNA and can use nucleosomes as substrates for integration. Here the authors present the 3.9 Å cryo-EM structure of prototype foamy virus integrase after strand transfer into nucleosomal DNA, which together with single-molecule FRET measurements provides evidence for a DNA looping and sliding mechanism of integrases.
format	article
author	Marcus D. Wilson Ludovic Renault Daniel P. Maskell Mohamed Ghoneim Valerie E. Pye Andrea Nans David S. Rueda Peter Cherepanov Alessandro Costa
author_facet	Marcus D. Wilson Ludovic Renault Daniel P. Maskell Mohamed Ghoneim Valerie E. Pye Andrea Nans David S. Rueda Peter Cherepanov Alessandro Costa
author_sort	Marcus D. Wilson
title	Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer
title_short	Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer
title_full	Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer
title_fullStr	Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer
title_full_unstemmed	Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer
title_sort	retroviral integration into nucleosomes through dna looping and sliding along the histone octamer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/81003a4887374f70b3a53f31395ad7bb
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Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

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