Genetic Landscape and Emerging Therapies in Uveal Melanoma

Despite successful treatment of primary uveal melanoma, up to 50% of patients will develop systemic metastasis. Metastatic disease portends a poor outcome, and no adjuvant or metastatic therapy has been FDA approved. The genetic landscape of uveal melanoma is unique, providing prognostic and potenti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rino S. Seedor, Marlana Orloff, Takami Sato
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	uveal melanoma metastatic uveal melanoma genetic landscape targeted therapy treatment strategy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8101a6b7c1cd4916b4648fdac49fccaa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8101a6b7c1cd4916b4648fdac49fccaa
record_format	dspace
spelling	oai:doaj.org-article:8101a6b7c1cd4916b4648fdac49fccaa2021-11-11T15:33:45ZGenetic Landscape and Emerging Therapies in Uveal Melanoma10.3390/cancers132155032072-6694https://doaj.org/article/8101a6b7c1cd4916b4648fdac49fccaa2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5503https://doaj.org/toc/2072-6694Despite successful treatment of primary uveal melanoma, up to 50% of patients will develop systemic metastasis. Metastatic disease portends a poor outcome, and no adjuvant or metastatic therapy has been FDA approved. The genetic landscape of uveal melanoma is unique, providing prognostic and potentially therapeutic insight. In this review, we discuss our current understanding of the molecular and cytogenetic mutations in uveal melanoma, and the importance of obtaining such information. Most of our knowledge is based on primary uveal melanoma and a better understanding of the mutational landscape in metastatic uveal melanoma is needed. Clinical trials targeting certain mutations such as <i>GNAQ</i>/<i>GNA11</i>, <i>BAP1</i>, and <i>SF3B1</i> are ongoing and promising. We also discuss the role of liquid biopsies in uveal melanoma in this review.Rino S. SeedorMarlana OrloffTakami SatoMDPI AGarticleuveal melanomametastatic uveal melanomagenetic landscapetargeted therapytreatment strategyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5503, p 5503 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	uveal melanoma metastatic uveal melanoma genetic landscape targeted therapy treatment strategy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	uveal melanoma metastatic uveal melanoma genetic landscape targeted therapy treatment strategy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Rino S. Seedor Marlana Orloff Takami Sato Genetic Landscape and Emerging Therapies in Uveal Melanoma
description	Despite successful treatment of primary uveal melanoma, up to 50% of patients will develop systemic metastasis. Metastatic disease portends a poor outcome, and no adjuvant or metastatic therapy has been FDA approved. The genetic landscape of uveal melanoma is unique, providing prognostic and potentially therapeutic insight. In this review, we discuss our current understanding of the molecular and cytogenetic mutations in uveal melanoma, and the importance of obtaining such information. Most of our knowledge is based on primary uveal melanoma and a better understanding of the mutational landscape in metastatic uveal melanoma is needed. Clinical trials targeting certain mutations such as <i>GNAQ</i>/<i>GNA11</i>, <i>BAP1</i>, and <i>SF3B1</i> are ongoing and promising. We also discuss the role of liquid biopsies in uveal melanoma in this review.
format	article
author	Rino S. Seedor Marlana Orloff Takami Sato
author_facet	Rino S. Seedor Marlana Orloff Takami Sato
author_sort	Rino S. Seedor
title	Genetic Landscape and Emerging Therapies in Uveal Melanoma
title_short	Genetic Landscape and Emerging Therapies in Uveal Melanoma
title_full	Genetic Landscape and Emerging Therapies in Uveal Melanoma
title_fullStr	Genetic Landscape and Emerging Therapies in Uveal Melanoma
title_full_unstemmed	Genetic Landscape and Emerging Therapies in Uveal Melanoma
title_sort	genetic landscape and emerging therapies in uveal melanoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8101a6b7c1cd4916b4648fdac49fccaa
work_keys_str_mv	AT rinosseedor geneticlandscapeandemergingtherapiesinuvealmelanoma AT marlanaorloff geneticlandscapeandemergingtherapiesinuvealmelanoma AT takamisato geneticlandscapeandemergingtherapiesinuvealmelanoma
_version_	1718435190962913280

Genetic Landscape and Emerging Therapies in Uveal Melanoma

Ejemplares similares