EFFECT OF TRANSPLANTATION OF IMMUNOCOMPETENT CELLS TREATED WITH CAFFEINE ON THE PARAMETERS OF THE NERVOUS SYSTEM FUNCTIONAL ACTIVITY
It was demonstrated that in vitro treatment with caffeine splenocytes of mice (CBAxC57Bl / 6) F1 with a passive type of behavior in «open field» modifies the functional activity of these cells, manifested in changes in spontaneous and induced cytokine production; the intravenous injection of these c...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
Scientific Сentre for Family Health and Human Reproduction Problems
2012
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/8103448f58304dffad7980a1f92cf7df |
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| Sumario: | It was demonstrated that in vitro treatment with caffeine splenocytes of mice (CBAxC57Bl / 6) F1 with a passive type of behavior in «open field» modifies the functional activity of these cells, manifested in changes in spontaneous and induced cytokine production; the intravenous injection of these cells is accompanied by modulation of the parameters of the motor and exploratory activity of recipients, the nature of which depends on the dose of caffeine. At the same time were shown some changes in the synthesis of cytokines by brain cells of mice-recipients. Possible mechanisms for modulating effect of transplanted immune cells on recipient's behavior were discussed. |
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