RNA m6A methylation regulators in ovarian cancer

Abstract N6-methyladenosine (m6A) is the most abundant RNA modification of mammalian mRNAs and plays a vital role in many diseases, especially tumours. In recent years, m6A has become the topic of intense discussion in epigenetics. M6A modification is dynamically regulated by methyltransferases, dem...

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Autores principales:	Jialu Guo, Jianfeng Zheng, Huizhi Zhang, Jinyi Tong
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Ovarian cancer Biomarker N6-methyladenosine Regulators Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/8109343cc80e4d1d97e0ce7a290795f2
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id	oai:doaj.org-article:8109343cc80e4d1d97e0ce7a290795f2
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spelling	oai:doaj.org-article:8109343cc80e4d1d97e0ce7a290795f22021-11-21T12:39:36ZRNA m6A methylation regulators in ovarian cancer10.1186/s12935-021-02318-81475-2867https://doaj.org/article/8109343cc80e4d1d97e0ce7a290795f22021-11-01T00:00:00Zhttps://doi.org/10.1186/s12935-021-02318-8https://doaj.org/toc/1475-2867Abstract N6-methyladenosine (m6A) is the most abundant RNA modification of mammalian mRNAs and plays a vital role in many diseases, especially tumours. In recent years, m6A has become the topic of intense discussion in epigenetics. M6A modification is dynamically regulated by methyltransferases, demethylases and RNA-binding proteins. Ovarian cancer (OC) is a common but highly fatal malignancy in female. Increasing evidence shows that changes in m6A levels and the dysregulation of m6A regulators are associated with the occurrence, development or prognosis of OC. In this review, the latest studies on m6A and its regulators in OC have been summarized, and we focus on the key role of m6A modification in the development and progression of OC. Additionally, we also discuss the potential use of m6A modification and its regulators in the diagnosis and treatment of OC.Jialu GuoJianfeng ZhengHuizhi ZhangJinyi TongBMCarticleOvarian cancerBiomarkerN6-methyladenosineRegulatorsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENCancer Cell International, Vol 21, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ovarian cancer Biomarker N6-methyladenosine Regulators Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
spellingShingle	Ovarian cancer Biomarker N6-methyladenosine Regulators Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Jialu Guo Jianfeng Zheng Huizhi Zhang Jinyi Tong RNA m6A methylation regulators in ovarian cancer
description	Abstract N6-methyladenosine (m6A) is the most abundant RNA modification of mammalian mRNAs and plays a vital role in many diseases, especially tumours. In recent years, m6A has become the topic of intense discussion in epigenetics. M6A modification is dynamically regulated by methyltransferases, demethylases and RNA-binding proteins. Ovarian cancer (OC) is a common but highly fatal malignancy in female. Increasing evidence shows that changes in m6A levels and the dysregulation of m6A regulators are associated with the occurrence, development or prognosis of OC. In this review, the latest studies on m6A and its regulators in OC have been summarized, and we focus on the key role of m6A modification in the development and progression of OC. Additionally, we also discuss the potential use of m6A modification and its regulators in the diagnosis and treatment of OC.
format	article
author	Jialu Guo Jianfeng Zheng Huizhi Zhang Jinyi Tong
author_facet	Jialu Guo Jianfeng Zheng Huizhi Zhang Jinyi Tong
author_sort	Jialu Guo
title	RNA m6A methylation regulators in ovarian cancer
title_short	RNA m6A methylation regulators in ovarian cancer
title_full	RNA m6A methylation regulators in ovarian cancer
title_fullStr	RNA m6A methylation regulators in ovarian cancer
title_full_unstemmed	RNA m6A methylation regulators in ovarian cancer
title_sort	rna m6a methylation regulators in ovarian cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/8109343cc80e4d1d97e0ce7a290795f2
work_keys_str_mv	AT jialuguo rnam6amethylationregulatorsinovariancancer AT jianfengzheng rnam6amethylationregulatorsinovariancancer AT huizhizhang rnam6amethylationregulatorsinovariancancer AT jinyitong rnam6amethylationregulatorsinovariancancer
_version_	1718418894527397888

RNA m6A methylation regulators in ovarian cancer

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