Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia

Some genes that are part of balanced translocations are reported as drivers for tumourigenesis. Here, the authors report a translocation involving MTCP1 in chronic lymphocytic leukemia and show that MTCP1 overexpression leads to the disease in a murine model.

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Autores principales:	Janek S. Walker, Zachary A. Hing, Steven Sher, James Cronin, Katie Williams, Bonnie Harrington, Jordan N. Skinner, Casey B. Cempre, Charles T. Gregory, Alexander Pan, Max Yano, Larry P. Beaver, Brandi R. Walker, Jadwiga M. Labanowska, Nyla A. Heerema, Krzysztof Mrózek, Jennifer A. Woyach, Amy S. Ruppert, Amy Lehman, Hatice Gulcin Ozer, Vincenzo Coppola, Pearlly Yan, John C. Byrd, James S. Blachly, Rosa Lapalombella
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/810bfd0089064a989b380ab83b7f18b0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:810bfd0089064a989b380ab83b7f18b02021-11-08T11:12:04ZRare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia10.1038/s41467-021-26400-x2041-1723https://doaj.org/article/810bfd0089064a989b380ab83b7f18b02021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26400-xhttps://doaj.org/toc/2041-1723Some genes that are part of balanced translocations are reported as drivers for tumourigenesis. Here, the authors report a translocation involving MTCP1 in chronic lymphocytic leukemia and show that MTCP1 overexpression leads to the disease in a murine model.Janek S. WalkerZachary A. HingSteven SherJames CroninKatie WilliamsBonnie HarringtonJordan N. SkinnerCasey B. CempreCharles T. GregoryAlexander PanMax YanoLarry P. BeaverBrandi R. WalkerJadwiga M. LabanowskaNyla A. HeeremaKrzysztof MrózekJennifer A. WoyachAmy S. RuppertAmy LehmanHatice Gulcin OzerVincenzo CoppolaPearlly YanJohn C. ByrdJames S. BlachlyRosa LapalombellaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Janek S. Walker Zachary A. Hing Steven Sher James Cronin Katie Williams Bonnie Harrington Jordan N. Skinner Casey B. Cempre Charles T. Gregory Alexander Pan Max Yano Larry P. Beaver Brandi R. Walker Jadwiga M. Labanowska Nyla A. Heerema Krzysztof Mrózek Jennifer A. Woyach Amy S. Ruppert Amy Lehman Hatice Gulcin Ozer Vincenzo Coppola Pearlly Yan John C. Byrd James S. Blachly Rosa Lapalombella Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia
description	Some genes that are part of balanced translocations are reported as drivers for tumourigenesis. Here, the authors report a translocation involving MTCP1 in chronic lymphocytic leukemia and show that MTCP1 overexpression leads to the disease in a murine model.
format	article
author	Janek S. Walker Zachary A. Hing Steven Sher James Cronin Katie Williams Bonnie Harrington Jordan N. Skinner Casey B. Cempre Charles T. Gregory Alexander Pan Max Yano Larry P. Beaver Brandi R. Walker Jadwiga M. Labanowska Nyla A. Heerema Krzysztof Mrózek Jennifer A. Woyach Amy S. Ruppert Amy Lehman Hatice Gulcin Ozer Vincenzo Coppola Pearlly Yan John C. Byrd James S. Blachly Rosa Lapalombella
author_facet	Janek S. Walker Zachary A. Hing Steven Sher James Cronin Katie Williams Bonnie Harrington Jordan N. Skinner Casey B. Cempre Charles T. Gregory Alexander Pan Max Yano Larry P. Beaver Brandi R. Walker Jadwiga M. Labanowska Nyla A. Heerema Krzysztof Mrózek Jennifer A. Woyach Amy S. Ruppert Amy Lehman Hatice Gulcin Ozer Vincenzo Coppola Pearlly Yan John C. Byrd James S. Blachly Rosa Lapalombella
author_sort	Janek S. Walker
title	Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia
title_short	Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia
title_full	Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia
title_fullStr	Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia
title_full_unstemmed	Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia
title_sort	rare t(x;14)(q28;q32) translocation reveals link between mtcp1 and chronic lymphocytic leukemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/810bfd0089064a989b380ab83b7f18b0
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Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia

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