Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.
<h4>Background and aims</h4>Despite the high prevalence of chronic hepatitis B (CHB) in Africa, few studies have been performed among African patients. We sought to evaluate liver stiffness measurement by FibroScan® (LSM) and two biochemical scores (FibroTest®, Fibrometer®) to diagnose l...
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2011
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oai:doaj.org-article:810c4f67a0fa439ca27921dbd5f90ea62021-11-18T06:49:31ZLiver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.1932-620310.1371/journal.pone.0022291https://doaj.org/article/810c4f67a0fa439ca27921dbd5f90ea62011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21799814/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and aims</h4>Despite the high prevalence of chronic hepatitis B (CHB) in Africa, few studies have been performed among African patients. We sought to evaluate liver stiffness measurement by FibroScan® (LSM) and two biochemical scores (FibroTest®, Fibrometer®) to diagnose liver fibrosis in Senegalese CHB patients with HBV plasma DNA load ≥3.2 log(10) IU/mL and normal alanine aminotransferase (ALT) values.<h4>Methods</h4>LSM and liver fibrosis biochemical markers were performed on 225 consecutive HBV infected Senegalese patients with high viral load. Patients with an LSM range between 7 and 13 kPa underwent liver biopsy (LB). Two experienced liver pathologists performed histological grading using Metavir and Ishak scoring.<h4>Results</h4>225 patients were evaluated (84% male) and LB was performed in 69 patients, showing F2 and F3 fibrosis in 17% and 10% respectively. In these patients with a 7-13 kPa range of LSM, accuracy for diagnosis of significant fibrosis according to LB was unsatisfactory for all non-invasive markers with AUROCs below 0.70. For patients with LSM values below 7 kPa, FibroTest® (FT), and Fibrometer® (FM) using the cut-offs recommended by the test promoters suggested a fibrosis in 18% of cases for FT (8% severe fibrosis) and 8% for FM. For patients with LSM values greater than 13 kPa, FT, FM suggested a possible fibrosis in 73% and 70%, respectively.<h4>Conclusion</h4>In highly replicative HBV-infected African patients with normal ALT and LSM value below 13 kPa, FibroScan®, FibroTest® or Fibrometer® were unsuitable to predict the histological liver status of fibrosis.Papa Saliou MbayeAnna SarrJean-Marie SireMarie-Louise EvraAdama BaJean DaveigaAboubakry DialloFatou FallLoic ChartierFrançois SimonMuriel VrayPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22291 (2011) |
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Medicine R Science Q Papa Saliou Mbaye Anna Sarr Jean-Marie Sire Marie-Louise Evra Adama Ba Jean Daveiga Aboubakry Diallo Fatou Fall Loic Chartier François Simon Muriel Vray Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load. |
| description |
<h4>Background and aims</h4>Despite the high prevalence of chronic hepatitis B (CHB) in Africa, few studies have been performed among African patients. We sought to evaluate liver stiffness measurement by FibroScan® (LSM) and two biochemical scores (FibroTest®, Fibrometer®) to diagnose liver fibrosis in Senegalese CHB patients with HBV plasma DNA load ≥3.2 log(10) IU/mL and normal alanine aminotransferase (ALT) values.<h4>Methods</h4>LSM and liver fibrosis biochemical markers were performed on 225 consecutive HBV infected Senegalese patients with high viral load. Patients with an LSM range between 7 and 13 kPa underwent liver biopsy (LB). Two experienced liver pathologists performed histological grading using Metavir and Ishak scoring.<h4>Results</h4>225 patients were evaluated (84% male) and LB was performed in 69 patients, showing F2 and F3 fibrosis in 17% and 10% respectively. In these patients with a 7-13 kPa range of LSM, accuracy for diagnosis of significant fibrosis according to LB was unsatisfactory for all non-invasive markers with AUROCs below 0.70. For patients with LSM values below 7 kPa, FibroTest® (FT), and Fibrometer® (FM) using the cut-offs recommended by the test promoters suggested a fibrosis in 18% of cases for FT (8% severe fibrosis) and 8% for FM. For patients with LSM values greater than 13 kPa, FT, FM suggested a possible fibrosis in 73% and 70%, respectively.<h4>Conclusion</h4>In highly replicative HBV-infected African patients with normal ALT and LSM value below 13 kPa, FibroScan®, FibroTest® or Fibrometer® were unsuitable to predict the histological liver status of fibrosis. |
| format |
article |
| author |
Papa Saliou Mbaye Anna Sarr Jean-Marie Sire Marie-Louise Evra Adama Ba Jean Daveiga Aboubakry Diallo Fatou Fall Loic Chartier François Simon Muriel Vray |
| author_facet |
Papa Saliou Mbaye Anna Sarr Jean-Marie Sire Marie-Louise Evra Adama Ba Jean Daveiga Aboubakry Diallo Fatou Fall Loic Chartier François Simon Muriel Vray |
| author_sort |
Papa Saliou Mbaye |
| title |
Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load. |
| title_short |
Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load. |
| title_full |
Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load. |
| title_fullStr |
Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load. |
| title_full_unstemmed |
Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load. |
| title_sort |
liver stiffness measurement and biochemical markers in senegalese chronic hepatitis b patients with normal alt and high viral load. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/810c4f67a0fa439ca27921dbd5f90ea6 |
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