Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair

Dense connective tissues do not easily heal, in part due to a low supply of reparative cells. Here, the authors develop a fibrous scaffold for meniscal repair that sequentially releases collagenase and a growth factor at the injury site, breaking down the extracellular matrix and recruiting endogeno...

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Autores principales:	Feini Qu, Julianne L. Holloway, John L. Esterhai, Jason A. Burdick, Robert L. Mauck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/810e049ef0d64a378aa7c4e74e8cdf7e
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spelling	oai:doaj.org-article:810e049ef0d64a378aa7c4e74e8cdf7e2021-12-02T14:40:37ZProgrammed biomolecule delivery to enable and direct cell migration for connective tissue repair10.1038/s41467-017-01955-w2041-1723https://doaj.org/article/810e049ef0d64a378aa7c4e74e8cdf7e2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01955-whttps://doaj.org/toc/2041-1723Dense connective tissues do not easily heal, in part due to a low supply of reparative cells. Here, the authors develop a fibrous scaffold for meniscal repair that sequentially releases collagenase and a growth factor at the injury site, breaking down the extracellular matrix and recruiting endogenous cells.Feini QuJulianne L. HollowayJohn L. EsterhaiJason A. BurdickRobert L. MauckNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Feini Qu Julianne L. Holloway John L. Esterhai Jason A. Burdick Robert L. Mauck Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair
description	Dense connective tissues do not easily heal, in part due to a low supply of reparative cells. Here, the authors develop a fibrous scaffold for meniscal repair that sequentially releases collagenase and a growth factor at the injury site, breaking down the extracellular matrix and recruiting endogenous cells.
format	article
author	Feini Qu Julianne L. Holloway John L. Esterhai Jason A. Burdick Robert L. Mauck
author_facet	Feini Qu Julianne L. Holloway John L. Esterhai Jason A. Burdick Robert L. Mauck
author_sort	Feini Qu
title	Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair
title_short	Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair
title_full	Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair
title_fullStr	Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair
title_full_unstemmed	Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair
title_sort	programmed biomolecule delivery to enable and direct cell migration for connective tissue repair
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/810e049ef0d64a378aa7c4e74e8cdf7e
work_keys_str_mv	AT feiniqu programmedbiomoleculedeliverytoenableanddirectcellmigrationforconnectivetissuerepair AT juliannelholloway programmedbiomoleculedeliverytoenableanddirectcellmigrationforconnectivetissuerepair AT johnlesterhai programmedbiomoleculedeliverytoenableanddirectcellmigrationforconnectivetissuerepair AT jasonaburdick programmedbiomoleculedeliverytoenableanddirectcellmigrationforconnectivetissuerepair AT robertlmauck programmedbiomoleculedeliverytoenableanddirectcellmigrationforconnectivetissuerepair
_version_	1718390248425127936

Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair

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