Time-varying regularity of changes in biomechanical properties of the corneas after removal of anterior corneal tissue

Abstract Background The corneal biomechanical properties with the prolongation of time after corneal refractive surgery are important for providing a mechanical basis for the occurrence of clinical phenomena such as iatrogenic keratectasia and refractive regression. The aim of this study was to expl...

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Autores principales:	Di Zhang, Xiao Qin, Haixia Zhang, Lin Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Corneal elastic modulus Stress relaxation Uniaxial tests Corneal refractive surgery Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/810e60cd1f1d4bd0a2e713245583d842
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spelling	oai:doaj.org-article:810e60cd1f1d4bd0a2e713245583d8422021-11-21T12:12:19ZTime-varying regularity of changes in biomechanical properties of the corneas after removal of anterior corneal tissue10.1186/s12938-021-00948-71475-925Xhttps://doaj.org/article/810e60cd1f1d4bd0a2e713245583d8422021-11-01T00:00:00Zhttps://doi.org/10.1186/s12938-021-00948-7https://doaj.org/toc/1475-925XAbstract Background The corneal biomechanical properties with the prolongation of time after corneal refractive surgery are important for providing a mechanical basis for the occurrence of clinical phenomena such as iatrogenic keratectasia and refractive regression. The aim of this study was to explore the changes of corneal elastic modulus, and stress relaxation properties from the 6-month follow-up observations of rabbits after a removal of anterior corneal tissue in simulation to corneal refractive surgery. Methods The anterior corneal tissue, 6 mm in diameter and 30–50% of the original corneal thickness, the left eye of the rabbit was removed, and the right eye was kept as the control. The rabbits were normally raised and nursed for 6 months, during which corneal morphology data, and both of corneal hysteresis (CH) and corneal resistance factor (CRF) were gathered. Uniaxial tensile tests of corneal strips were performed at months 1, 3, and 6 from 7 animals, and corneal collagen fibrils were observed at months 1, 3, and 6 from 1 rabbit, respectively. Results Compared with the control group, there were statistical differences in the curvature radius at week 2 and month 3, and both CH and CRF at months 1, 2, and 6 in experiment group; there were statistical differences in elastic modulus at 1, 3, and month 6, and stress relaxation degree at month 3 in experiment group. The differences in corneal elastic modulus, stress relaxation degree and the total number of collagen fibrils between experiment and control groups varied gradually with time, and showed significant changes at the 3rd month after the treatment. Conclusions Corneas after a removal of anterior corneal tissue undergo dynamic changes in corneal morphology and biomechanical properties. The first 3 months after treatment could be a critical period. The variation of corneal biomechanical properties is worth considering in predicting corneal deformation after a removal of anterior corneal tissue.Di ZhangXiao QinHaixia ZhangLin LiBMCarticleCorneal elastic modulusStress relaxationUniaxial testsCorneal refractive surgeryMedical technologyR855-855.5ENBioMedical Engineering OnLine, Vol 20, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Corneal elastic modulus Stress relaxation Uniaxial tests Corneal refractive surgery Medical technology R855-855.5
spellingShingle	Corneal elastic modulus Stress relaxation Uniaxial tests Corneal refractive surgery Medical technology R855-855.5 Di Zhang Xiao Qin Haixia Zhang Lin Li Time-varying regularity of changes in biomechanical properties of the corneas after removal of anterior corneal tissue
description	Abstract Background The corneal biomechanical properties with the prolongation of time after corneal refractive surgery are important for providing a mechanical basis for the occurrence of clinical phenomena such as iatrogenic keratectasia and refractive regression. The aim of this study was to explore the changes of corneal elastic modulus, and stress relaxation properties from the 6-month follow-up observations of rabbits after a removal of anterior corneal tissue in simulation to corneal refractive surgery. Methods The anterior corneal tissue, 6 mm in diameter and 30–50% of the original corneal thickness, the left eye of the rabbit was removed, and the right eye was kept as the control. The rabbits were normally raised and nursed for 6 months, during which corneal morphology data, and both of corneal hysteresis (CH) and corneal resistance factor (CRF) were gathered. Uniaxial tensile tests of corneal strips were performed at months 1, 3, and 6 from 7 animals, and corneal collagen fibrils were observed at months 1, 3, and 6 from 1 rabbit, respectively. Results Compared with the control group, there were statistical differences in the curvature radius at week 2 and month 3, and both CH and CRF at months 1, 2, and 6 in experiment group; there were statistical differences in elastic modulus at 1, 3, and month 6, and stress relaxation degree at month 3 in experiment group. The differences in corneal elastic modulus, stress relaxation degree and the total number of collagen fibrils between experiment and control groups varied gradually with time, and showed significant changes at the 3rd month after the treatment. Conclusions Corneas after a removal of anterior corneal tissue undergo dynamic changes in corneal morphology and biomechanical properties. The first 3 months after treatment could be a critical period. The variation of corneal biomechanical properties is worth considering in predicting corneal deformation after a removal of anterior corneal tissue.
format	article
author	Di Zhang Xiao Qin Haixia Zhang Lin Li
author_facet	Di Zhang Xiao Qin Haixia Zhang Lin Li
author_sort	Di Zhang
title	Time-varying regularity of changes in biomechanical properties of the corneas after removal of anterior corneal tissue
title_short	Time-varying regularity of changes in biomechanical properties of the corneas after removal of anterior corneal tissue
title_full	Time-varying regularity of changes in biomechanical properties of the corneas after removal of anterior corneal tissue
title_fullStr	Time-varying regularity of changes in biomechanical properties of the corneas after removal of anterior corneal tissue
title_full_unstemmed	Time-varying regularity of changes in biomechanical properties of the corneas after removal of anterior corneal tissue
title_sort	time-varying regularity of changes in biomechanical properties of the corneas after removal of anterior corneal tissue
publisher	BMC
publishDate	2021
url	https://doaj.org/article/810e60cd1f1d4bd0a2e713245583d842
work_keys_str_mv	AT dizhang timevaryingregularityofchangesinbiomechanicalpropertiesofthecorneasafterremovalofanteriorcornealtissue AT xiaoqin timevaryingregularityofchangesinbiomechanicalpropertiesofthecorneasafterremovalofanteriorcornealtissue AT haixiazhang timevaryingregularityofchangesinbiomechanicalpropertiesofthecorneasafterremovalofanteriorcornealtissue AT linli timevaryingregularityofchangesinbiomechanicalpropertiesofthecorneasafterremovalofanteriorcornealtissue
_version_	1718419133403496448

Time-varying regularity of changes in biomechanical properties of the corneas after removal of anterior corneal tissue

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