Biogenesis and functions of aminocarboxypropyluridine in tRNA

E. coli and human tRNAs contain 3-(3-amino-3-carboxypropyl)uridine (acp3U) modification. Here the authors identify E. coli TapT and human DTWD1/2 as tRNA aminocarboxypropyltransferases responsible for acp3U formation. Inhibition of acp3U modification results in genome instability in heat-stressed E....

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Autores principales:	Mayuko Takakura, Kensuke Ishiguro, Shinichiro Akichika, Kenjyo Miyauchi, Tsutomu Suzuki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81134aa922094666bad2505d7c7debc0
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spelling	oai:doaj.org-article:81134aa922094666bad2505d7c7debc02021-12-02T14:39:39ZBiogenesis and functions of aminocarboxypropyluridine in tRNA10.1038/s41467-019-13525-32041-1723https://doaj.org/article/81134aa922094666bad2505d7c7debc02019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13525-3https://doaj.org/toc/2041-1723E. coli and human tRNAs contain 3-(3-amino-3-carboxypropyl)uridine (acp3U) modification. Here the authors identify E. coli TapT and human DTWD1/2 as tRNA aminocarboxypropyltransferases responsible for acp3U formation. Inhibition of acp3U modification results in genome instability in heat-stressed E. coli and growth defects in human cells.Mayuko TakakuraKensuke IshiguroShinichiro AkichikaKenjyo MiyauchiTsutomu SuzukiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mayuko Takakura Kensuke Ishiguro Shinichiro Akichika Kenjyo Miyauchi Tsutomu Suzuki Biogenesis and functions of aminocarboxypropyluridine in tRNA
description	E. coli and human tRNAs contain 3-(3-amino-3-carboxypropyl)uridine (acp3U) modification. Here the authors identify E. coli TapT and human DTWD1/2 as tRNA aminocarboxypropyltransferases responsible for acp3U formation. Inhibition of acp3U modification results in genome instability in heat-stressed E. coli and growth defects in human cells.
format	article
author	Mayuko Takakura Kensuke Ishiguro Shinichiro Akichika Kenjyo Miyauchi Tsutomu Suzuki
author_facet	Mayuko Takakura Kensuke Ishiguro Shinichiro Akichika Kenjyo Miyauchi Tsutomu Suzuki
author_sort	Mayuko Takakura
title	Biogenesis and functions of aminocarboxypropyluridine in tRNA
title_short	Biogenesis and functions of aminocarboxypropyluridine in tRNA
title_full	Biogenesis and functions of aminocarboxypropyluridine in tRNA
title_fullStr	Biogenesis and functions of aminocarboxypropyluridine in tRNA
title_full_unstemmed	Biogenesis and functions of aminocarboxypropyluridine in tRNA
title_sort	biogenesis and functions of aminocarboxypropyluridine in trna
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/81134aa922094666bad2505d7c7debc0
work_keys_str_mv	AT mayukotakakura biogenesisandfunctionsofaminocarboxypropyluridineintrna AT kensukeishiguro biogenesisandfunctionsofaminocarboxypropyluridineintrna AT shinichiroakichika biogenesisandfunctionsofaminocarboxypropyluridineintrna AT kenjyomiyauchi biogenesisandfunctionsofaminocarboxypropyluridineintrna AT tsutomusuzuki biogenesisandfunctionsofaminocarboxypropyluridineintrna
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Biogenesis and functions of aminocarboxypropyluridine in tRNA

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