The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation

Hsp90 is a molecular chaperone that acts together with co-chaperones to ensure folding and activation of many client proteins. Here authors show that a N-terminal motif in Aha-type co-chaperones modulates the apparent affinity of Hsp90 for nucleotide substrates.

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Autores principales:	Rebecca Mercier, Annemarie Wolmarans, Jonathan Schubert, Hannes Neuweiler, Jill L. Johnson, Paul LaPointe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/811850ffa23e4def955ea6a50a0c5a86
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spelling	oai:doaj.org-article:811850ffa23e4def955ea6a50a0c5a862021-12-02T17:01:39ZThe conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation10.1038/s41467-019-09299-32041-1723https://doaj.org/article/811850ffa23e4def955ea6a50a0c5a862019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09299-3https://doaj.org/toc/2041-1723Hsp90 is a molecular chaperone that acts together with co-chaperones to ensure folding and activation of many client proteins. Here authors show that a N-terminal motif in Aha-type co-chaperones modulates the apparent affinity of Hsp90 for nucleotide substrates.Rebecca MercierAnnemarie WolmaransJonathan SchubertHannes NeuweilerJill L. JohnsonPaul LaPointeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca Mercier Annemarie Wolmarans Jonathan Schubert Hannes Neuweiler Jill L. Johnson Paul LaPointe The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation
description	Hsp90 is a molecular chaperone that acts together with co-chaperones to ensure folding and activation of many client proteins. Here authors show that a N-terminal motif in Aha-type co-chaperones modulates the apparent affinity of Hsp90 for nucleotide substrates.
format	article
author	Rebecca Mercier Annemarie Wolmarans Jonathan Schubert Hannes Neuweiler Jill L. Johnson Paul LaPointe
author_facet	Rebecca Mercier Annemarie Wolmarans Jonathan Schubert Hannes Neuweiler Jill L. Johnson Paul LaPointe
author_sort	Rebecca Mercier
title	The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation
title_short	The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation
title_full	The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation
title_fullStr	The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation
title_full_unstemmed	The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation
title_sort	conserved nxnnwhw motif in aha-type co-chaperones modulates the kinetics of hsp90 atpase stimulation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/811850ffa23e4def955ea6a50a0c5a86
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The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation

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