Sarcopenia, sarcopenic obesity, myosteatosis as factors of poor prognosis in gastrointestinal tract tumors: review

Over the past decade, there has been a noticeable increase in the number of publications devoted to the analysis of body composition in the treatment of gastrointestinal malignancies. Sarcopenia (skeletal muscle depletion), sarcopenic obesity and myosteatosis are shown to have a negative impact on t...

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Autores principales:	Tatyana S. Dikova, Alina Y. Zatsepina, Denis S. Fedorinov, Vladimir K. Lyadov
Formato:	article
Lenguaje:	RU
Publicado:	IP Habib O.N. 2021
Materias:	cachexia sarcopenia sarcopenic obesity myosteatosis cancer gastro-intestinal tract Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/811910c2d8eb4c51a68d8224065c2f45
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spelling	oai:doaj.org-article:811910c2d8eb4c51a68d8224065c2f452021-11-30T16:55:01ZSarcopenia, sarcopenic obesity, myosteatosis as factors of poor prognosis in gastrointestinal tract tumors: review1815-14341815-144210.26442/18151434.2021.1.200715https://doaj.org/article/811910c2d8eb4c51a68d8224065c2f452021-05-01T00:00:00Zhttps://modernonco.orscience.ru/1815-1434/article/viewFile/70461/51388https://doaj.org/toc/1815-1434https://doaj.org/toc/1815-1442Over the past decade, there has been a noticeable increase in the number of publications devoted to the analysis of body composition in the treatment of gastrointestinal malignancies. Sarcopenia (skeletal muscle depletion), sarcopenic obesity and myosteatosis are shown to have a negative impact on the results of surgical and chemotherapeutic treatment of patients with gastrointestinal tumors. The review presents in detail data on clinical value of sarcopenia, sarcopenic obesity and myosteatosis along with methodological aspects of body composition analysis. Different cut-offs and diagnostic criteria exist between Western and Eastern patient populations which makes any comparison or meta-analysis not possible right now. The review presents data from Russian and foreign studies on the influence of body composition on postoperative outcomes and survival in patients with gastrointestinal tumors. The article also discusses the influence of body composition on dose-limiting toxicity of chemotherapy. We aimed at raising awareness of clinicians regarding the high prevalence of cancer cachexia and, precisely, sarcopenia, sarcopenic obesity and myosteatosis in patients with GI tract tumors. Deeper understanding of these syndromes is the key to developing measures for prevention as well as correcting the treatment of patients with gastrointestinal tumors.Tatyana S. DikovaAlina Y. ZatsepinaDenis S. FedorinovVladimir K. LyadovIP Habib O.N.articlecachexiasarcopeniasarcopenic obesitymyosteatosiscancergastro-intestinal tractNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282RUСовременная онкология, Vol 23, Iss 1, Pp 141-147 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	cachexia sarcopenia sarcopenic obesity myosteatosis cancer gastro-intestinal tract Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cachexia sarcopenia sarcopenic obesity myosteatosis cancer gastro-intestinal tract Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Tatyana S. Dikova Alina Y. Zatsepina Denis S. Fedorinov Vladimir K. Lyadov Sarcopenia, sarcopenic obesity, myosteatosis as factors of poor prognosis in gastrointestinal tract tumors: review
description	Over the past decade, there has been a noticeable increase in the number of publications devoted to the analysis of body composition in the treatment of gastrointestinal malignancies. Sarcopenia (skeletal muscle depletion), sarcopenic obesity and myosteatosis are shown to have a negative impact on the results of surgical and chemotherapeutic treatment of patients with gastrointestinal tumors. The review presents in detail data on clinical value of sarcopenia, sarcopenic obesity and myosteatosis along with methodological aspects of body composition analysis. Different cut-offs and diagnostic criteria exist between Western and Eastern patient populations which makes any comparison or meta-analysis not possible right now. The review presents data from Russian and foreign studies on the influence of body composition on postoperative outcomes and survival in patients with gastrointestinal tumors. The article also discusses the influence of body composition on dose-limiting toxicity of chemotherapy. We aimed at raising awareness of clinicians regarding the high prevalence of cancer cachexia and, precisely, sarcopenia, sarcopenic obesity and myosteatosis in patients with GI tract tumors. Deeper understanding of these syndromes is the key to developing measures for prevention as well as correcting the treatment of patients with gastrointestinal tumors.
format	article
author	Tatyana S. Dikova Alina Y. Zatsepina Denis S. Fedorinov Vladimir K. Lyadov
author_facet	Tatyana S. Dikova Alina Y. Zatsepina Denis S. Fedorinov Vladimir K. Lyadov
author_sort	Tatyana S. Dikova
title	Sarcopenia, sarcopenic obesity, myosteatosis as factors of poor prognosis in gastrointestinal tract tumors: review
title_short	Sarcopenia, sarcopenic obesity, myosteatosis as factors of poor prognosis in gastrointestinal tract tumors: review
title_full	Sarcopenia, sarcopenic obesity, myosteatosis as factors of poor prognosis in gastrointestinal tract tumors: review
title_fullStr	Sarcopenia, sarcopenic obesity, myosteatosis as factors of poor prognosis in gastrointestinal tract tumors: review
title_full_unstemmed	Sarcopenia, sarcopenic obesity, myosteatosis as factors of poor prognosis in gastrointestinal tract tumors: review
title_sort	sarcopenia, sarcopenic obesity, myosteatosis as factors of poor prognosis in gastrointestinal tract tumors: review
publisher	IP Habib O.N.
publishDate	2021
url	https://doaj.org/article/811910c2d8eb4c51a68d8224065c2f45
work_keys_str_mv	AT tatyanasdikova sarcopeniasarcopenicobesitymyosteatosisasfactorsofpoorprognosisingastrointestinaltracttumorsreview AT alinayzatsepina sarcopeniasarcopenicobesitymyosteatosisasfactorsofpoorprognosisingastrointestinaltracttumorsreview AT denissfedorinov sarcopeniasarcopenicobesitymyosteatosisasfactorsofpoorprognosisingastrointestinaltracttumorsreview AT vladimirklyadov sarcopeniasarcopenicobesitymyosteatosisasfactorsofpoorprognosisingastrointestinaltracttumorsreview
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Sarcopenia, sarcopenic obesity, myosteatosis as factors of poor prognosis in gastrointestinal tract tumors: review

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