Chapter 11: Genome-wide association studies.

Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease. In this work, we review the key concepts underlying GWAS, including the architecture of common diseases, the structure of common human genetic...

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Autores principales:	William S Bush, Jason H Moore
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/811aaf4095824b1ba6ec1fffb88b1ade
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spelling	oai:doaj.org-article:811aaf4095824b1ba6ec1fffb88b1ade2021-11-18T05:52:35ZChapter 11: Genome-wide association studies.1553-734X1553-735810.1371/journal.pcbi.1002822https://doaj.org/article/811aaf4095824b1ba6ec1fffb88b1ade2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300413/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease. In this work, we review the key concepts underlying GWAS, including the architecture of common diseases, the structure of common human genetic variation, technologies for capturing genetic information, study designs, and the statistical methods used for data analysis. We also look forward to the future beyond GWAS.William S BushJason H MoorePublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 12, p e1002822 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 William S Bush Jason H Moore Chapter 11: Genome-wide association studies.
description	Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease. In this work, we review the key concepts underlying GWAS, including the architecture of common diseases, the structure of common human genetic variation, technologies for capturing genetic information, study designs, and the statistical methods used for data analysis. We also look forward to the future beyond GWAS.
format	article
author	William S Bush Jason H Moore
author_facet	William S Bush Jason H Moore
author_sort	William S Bush
title	Chapter 11: Genome-wide association studies.
title_short	Chapter 11: Genome-wide association studies.
title_full	Chapter 11: Genome-wide association studies.
title_fullStr	Chapter 11: Genome-wide association studies.
title_full_unstemmed	Chapter 11: Genome-wide association studies.
title_sort	chapter 11: genome-wide association studies.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/811aaf4095824b1ba6ec1fffb88b1ade
work_keys_str_mv	AT williamsbush chapter11genomewideassociationstudies AT jasonhmoore chapter11genomewideassociationstudies
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Chapter 11: Genome-wide association studies.

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