Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice

Hematopoietic stem and progenitor cells are generated first from the vascular endothelium of the dorsal aorta and then the fetal liver but what regulates this switch is unknown. Here, the authors show that changing miRNA biogenesis and leukotriene B4 signaling in mice modulates this switch in the ni...

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Autores principales:	Xuan Jiang, John S. Hawkins, Jerry Lee, Carlos O. Lizama, Frank L. Bos, Joan P. Zape, Prajakta Ghatpande, Yongbo Peng, Justin Louie, Giorgio Lagna, Ann C. Zovein, Akiko Hata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/811b54bd0de3489e841c1856c5f439e4
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spelling	oai:doaj.org-article:811b54bd0de3489e841c1856c5f439e42021-12-02T13:57:54ZLet-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice10.1038/s41467-017-00137-y2041-1723https://doaj.org/article/811b54bd0de3489e841c1856c5f439e42017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00137-yhttps://doaj.org/toc/2041-1723Hematopoietic stem and progenitor cells are generated first from the vascular endothelium of the dorsal aorta and then the fetal liver but what regulates this switch is unknown. Here, the authors show that changing miRNA biogenesis and leukotriene B4 signaling in mice modulates this switch in the niche.Xuan JiangJohn S. HawkinsJerry LeeCarlos O. LizamaFrank L. BosJoan P. ZapePrajakta GhatpandeYongbo PengJustin LouieGiorgio LagnaAnn C. ZoveinAkiko HataNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xuan Jiang John S. Hawkins Jerry Lee Carlos O. Lizama Frank L. Bos Joan P. Zape Prajakta Ghatpande Yongbo Peng Justin Louie Giorgio Lagna Ann C. Zovein Akiko Hata Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice
description	Hematopoietic stem and progenitor cells are generated first from the vascular endothelium of the dorsal aorta and then the fetal liver but what regulates this switch is unknown. Here, the authors show that changing miRNA biogenesis and leukotriene B4 signaling in mice modulates this switch in the niche.
format	article
author	Xuan Jiang John S. Hawkins Jerry Lee Carlos O. Lizama Frank L. Bos Joan P. Zape Prajakta Ghatpande Yongbo Peng Justin Louie Giorgio Lagna Ann C. Zovein Akiko Hata
author_facet	Xuan Jiang John S. Hawkins Jerry Lee Carlos O. Lizama Frank L. Bos Joan P. Zape Prajakta Ghatpande Yongbo Peng Justin Louie Giorgio Lagna Ann C. Zovein Akiko Hata
author_sort	Xuan Jiang
title	Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice
title_short	Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice
title_full	Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice
title_fullStr	Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice
title_full_unstemmed	Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice
title_sort	let-7 microrna-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/811b54bd0de3489e841c1856c5f439e4
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Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice

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