Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

Deregulation of the RAS GTPase cycle due to mutations in RAS genes is commonly associated with cancer development. Here authors use NMR and mass spectrometry to shows that KRAS phosphorylation via Src alters the conformation of switch I and II regions and thereby impacts the GTPase cycle.

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Autores principales:	Yoshihito Kano, Teklab Gebregiworgis, Christopher B. Marshall, Nikolina Radulovich, Betty P. K. Poon, Jonathan St-Germain, Jonathan D. Cook, Ivette Valencia-Sama, Benjamin M. M. Grant, Silvia Gabriela Herrera, Jinmin Miao, Brian Raught, Meredith S. Irwin, Jeffrey E. Lee, Jen Jen Yeh, Zhong-Yin Zhang, Ming-Sound Tsao, Mitsuhiko Ikura, Michael Ohh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/811fdf81e7164853822f6750cc8b6260
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spelling	oai:doaj.org-article:811fdf81e7164853822f6750cc8b62602021-12-02T15:36:04ZTyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation10.1038/s41467-018-08115-82041-1723https://doaj.org/article/811fdf81e7164853822f6750cc8b62602019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08115-8https://doaj.org/toc/2041-1723Deregulation of the RAS GTPase cycle due to mutations in RAS genes is commonly associated with cancer development. Here authors use NMR and mass spectrometry to shows that KRAS phosphorylation via Src alters the conformation of switch I and II regions and thereby impacts the GTPase cycle.Yoshihito KanoTeklab GebregiworgisChristopher B. MarshallNikolina RadulovichBetty P. K. PoonJonathan St-GermainJonathan D. CookIvette Valencia-SamaBenjamin M. M. GrantSilvia Gabriela HerreraJinmin MiaoBrian RaughtMeredith S. IrwinJeffrey E. LeeJen Jen YehZhong-Yin ZhangMing-Sound TsaoMitsuhiko IkuraMichael OhhNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yoshihito Kano Teklab Gebregiworgis Christopher B. Marshall Nikolina Radulovich Betty P. K. Poon Jonathan St-Germain Jonathan D. Cook Ivette Valencia-Sama Benjamin M. M. Grant Silvia Gabriela Herrera Jinmin Miao Brian Raught Meredith S. Irwin Jeffrey E. Lee Jen Jen Yeh Zhong-Yin Zhang Ming-Sound Tsao Mitsuhiko Ikura Michael Ohh Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
description	Deregulation of the RAS GTPase cycle due to mutations in RAS genes is commonly associated with cancer development. Here authors use NMR and mass spectrometry to shows that KRAS phosphorylation via Src alters the conformation of switch I and II regions and thereby impacts the GTPase cycle.
format	article
author	Yoshihito Kano Teklab Gebregiworgis Christopher B. Marshall Nikolina Radulovich Betty P. K. Poon Jonathan St-Germain Jonathan D. Cook Ivette Valencia-Sama Benjamin M. M. Grant Silvia Gabriela Herrera Jinmin Miao Brian Raught Meredith S. Irwin Jeffrey E. Lee Jen Jen Yeh Zhong-Yin Zhang Ming-Sound Tsao Mitsuhiko Ikura Michael Ohh
author_facet	Yoshihito Kano Teklab Gebregiworgis Christopher B. Marshall Nikolina Radulovich Betty P. K. Poon Jonathan St-Germain Jonathan D. Cook Ivette Valencia-Sama Benjamin M. M. Grant Silvia Gabriela Herrera Jinmin Miao Brian Raught Meredith S. Irwin Jeffrey E. Lee Jen Jen Yeh Zhong-Yin Zhang Ming-Sound Tsao Mitsuhiko Ikura Michael Ohh
author_sort	Yoshihito Kano
title	Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
title_short	Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
title_full	Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
title_fullStr	Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
title_full_unstemmed	Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
title_sort	tyrosyl phosphorylation of kras stalls gtpase cycle via alteration of switch i and ii conformation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/811fdf81e7164853822f6750cc8b6260
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Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

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