Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

Cell-cell adhesion mediated by catenin-cadherin complexes plays a critical role in translating the mechanical forces into physiological responses. Here the authors define a mechanism of force-dependent cadherin-actin linkage dynamically regulated through the actin-binding domain of α-catenin.

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Autores principales: Noboru Ishiyama, Ritu Sarpal, Megan N. Wood, Samantha K. Barrick, Tadateru Nishikawa, Hanako Hayashi, Anna B. Kobb, Annette S. Flozak, Alex Yemelyanov, Rodrigo Fernandez-Gonzalez, Shigenobu Yonemura, Deborah E. Leckband, Cara J. Gottardi, Ulrich Tepass, Mitsuhiko Ikura
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/811fe916ab7f4aa8a28b241ddb5f61db
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