Blood-gas vs. Central-Laboratory analyzers: interchangeability and reference intervals for sodium, potassium, glucose, lactate and hemoglobin

Background: Blood-Gas Analyzers (BGAs) are commonly used in parallel with central laboratory analyzers (CLAs). Given the often-divergent results between BGAs and CLAs this study aims to: 1. Determine whether the measurements of potassium (K), sodium (Na), glucose (Glu), lactate (Lact) and total hemo...

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Autores principales:	Kocijancic Marija, Kraus Frank Bernhard, Ludwig-Kraus Beatrice
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	POCT Blood-gas analyzers Central-laboratory analyzers Interchangeability Reference intervals Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/812199f9f4b64983aa4eb4eca09592dc
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spelling	oai:doaj.org-article:812199f9f4b64983aa4eb4eca09592dc2021-12-02T05:02:31ZBlood-gas vs. Central-Laboratory analyzers: interchangeability and reference intervals for sodium, potassium, glucose, lactate and hemoglobin2405-844010.1016/j.heliyon.2021.e08302https://doaj.org/article/812199f9f4b64983aa4eb4eca09592dc2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021024051https://doaj.org/toc/2405-8440Background: Blood-Gas Analyzers (BGAs) are commonly used in parallel with central laboratory analyzers (CLAs). Given the often-divergent results between BGAs and CLAs this study aims to: 1. Determine whether the measurements of potassium (K), sodium (Na), glucose (Glu), lactate (Lact) and total hemoglobin (ctHb) on BGAs and CLAs are interchangeable; 2. Establish reference intervals (RIs) for both analyzer systems using an indirect statistical approach. Methods: During a one-year study period K, Na, Glu, Lact and ctHb measurements from 500 arterial blood samples, measured on ABL 90 FLEX BGAs were compared with corresponding venous samples measured on Roche c8000 and Sysmex XN-9000 analyzers. Interchangeability of methods was tested based on the Acceptable Change Limit, Total Change Limit and the guidelines published by the German Medical Association for quality assurance in medical laboratories criteria. Indirect RIs were estimated based on all routine analysis data using the software Reference Limit Estimator (RLE). Results: With the exception of Na, the BGAs differed significantly from the CLAs for the tested analytes (P < 0.001) but, with the exception of ctHb, did meet the interchangeability criteria. For K, Na, Gluc and ctHb the reference intervals obtained with RLE did not differ statistically between the analyzer systems. Conclusion: The interchangeability criteria were met for Na, K and Gluc and Lact. The indirect RIs obtained with RLE, are comparable between two systems for Na, K, Gluc an ctHb. Lact differed significantly in the lower reference limit between the BGAs and CLAs. The simultaneous use of both analyzing systems is thus only advisable for Na, K and Gluc.Kocijancic MarijaKraus Frank BernhardLudwig-Kraus BeatriceElsevierarticlePOCTBlood-gas analyzersCentral-laboratory analyzersInterchangeabilityReference intervalsScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08302- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	POCT Blood-gas analyzers Central-laboratory analyzers Interchangeability Reference intervals Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	POCT Blood-gas analyzers Central-laboratory analyzers Interchangeability Reference intervals Science (General) Q1-390 Social sciences (General) H1-99 Kocijancic Marija Kraus Frank Bernhard Ludwig-Kraus Beatrice Blood-gas vs. Central-Laboratory analyzers: interchangeability and reference intervals for sodium, potassium, glucose, lactate and hemoglobin
description	Background: Blood-Gas Analyzers (BGAs) are commonly used in parallel with central laboratory analyzers (CLAs). Given the often-divergent results between BGAs and CLAs this study aims to: 1. Determine whether the measurements of potassium (K), sodium (Na), glucose (Glu), lactate (Lact) and total hemoglobin (ctHb) on BGAs and CLAs are interchangeable; 2. Establish reference intervals (RIs) for both analyzer systems using an indirect statistical approach. Methods: During a one-year study period K, Na, Glu, Lact and ctHb measurements from 500 arterial blood samples, measured on ABL 90 FLEX BGAs were compared with corresponding venous samples measured on Roche c8000 and Sysmex XN-9000 analyzers. Interchangeability of methods was tested based on the Acceptable Change Limit, Total Change Limit and the guidelines published by the German Medical Association for quality assurance in medical laboratories criteria. Indirect RIs were estimated based on all routine analysis data using the software Reference Limit Estimator (RLE). Results: With the exception of Na, the BGAs differed significantly from the CLAs for the tested analytes (P < 0.001) but, with the exception of ctHb, did meet the interchangeability criteria. For K, Na, Gluc and ctHb the reference intervals obtained with RLE did not differ statistically between the analyzer systems. Conclusion: The interchangeability criteria were met for Na, K and Gluc and Lact. The indirect RIs obtained with RLE, are comparable between two systems for Na, K, Gluc an ctHb. Lact differed significantly in the lower reference limit between the BGAs and CLAs. The simultaneous use of both analyzing systems is thus only advisable for Na, K and Gluc.
format	article
author	Kocijancic Marija Kraus Frank Bernhard Ludwig-Kraus Beatrice
author_facet	Kocijancic Marija Kraus Frank Bernhard Ludwig-Kraus Beatrice
author_sort	Kocijancic Marija
title	Blood-gas vs. Central-Laboratory analyzers: interchangeability and reference intervals for sodium, potassium, glucose, lactate and hemoglobin
title_short	Blood-gas vs. Central-Laboratory analyzers: interchangeability and reference intervals for sodium, potassium, glucose, lactate and hemoglobin
title_full	Blood-gas vs. Central-Laboratory analyzers: interchangeability and reference intervals for sodium, potassium, glucose, lactate and hemoglobin
title_fullStr	Blood-gas vs. Central-Laboratory analyzers: interchangeability and reference intervals for sodium, potassium, glucose, lactate and hemoglobin
title_full_unstemmed	Blood-gas vs. Central-Laboratory analyzers: interchangeability and reference intervals for sodium, potassium, glucose, lactate and hemoglobin
title_sort	blood-gas vs. central-laboratory analyzers: interchangeability and reference intervals for sodium, potassium, glucose, lactate and hemoglobin
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/812199f9f4b64983aa4eb4eca09592dc
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Blood-gas vs. Central-Laboratory analyzers: interchangeability and reference intervals for sodium, potassium, glucose, lactate and hemoglobin

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