Prolonged bacterial lag time results in small colony variants that represent a sub-population of persisters

Persisters are bacterial subpopulations that are not killed by antibiotics even though they lack genetic resistance. Here, the authors show that persisters can manifest as small colony variants in clinical infections, and arise as a result of a long lag time in stress conditions including antibiotic...

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Autores principales:	Clément Vulin, Nadja Leimer, Markus Huemer, Martin Ackermann, Annelies S. Zinkernagel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/812279b4d2374954bb816ff97c4123c5
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spelling	oai:doaj.org-article:812279b4d2374954bb816ff97c4123c52021-12-02T14:41:16ZProlonged bacterial lag time results in small colony variants that represent a sub-population of persisters10.1038/s41467-018-06527-02041-1723https://doaj.org/article/812279b4d2374954bb816ff97c4123c52018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06527-0https://doaj.org/toc/2041-1723Persisters are bacterial subpopulations that are not killed by antibiotics even though they lack genetic resistance. Here, the authors show that persisters can manifest as small colony variants in clinical infections, and arise as a result of a long lag time in stress conditions including antibiotic exposure.Clément VulinNadja LeimerMarkus HuemerMartin AckermannAnnelies S. ZinkernagelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clément Vulin Nadja Leimer Markus Huemer Martin Ackermann Annelies S. Zinkernagel Prolonged bacterial lag time results in small colony variants that represent a sub-population of persisters
description	Persisters are bacterial subpopulations that are not killed by antibiotics even though they lack genetic resistance. Here, the authors show that persisters can manifest as small colony variants in clinical infections, and arise as a result of a long lag time in stress conditions including antibiotic exposure.
format	article
author	Clément Vulin Nadja Leimer Markus Huemer Martin Ackermann Annelies S. Zinkernagel
author_facet	Clément Vulin Nadja Leimer Markus Huemer Martin Ackermann Annelies S. Zinkernagel
author_sort	Clément Vulin
title	Prolonged bacterial lag time results in small colony variants that represent a sub-population of persisters
title_short	Prolonged bacterial lag time results in small colony variants that represent a sub-population of persisters
title_full	Prolonged bacterial lag time results in small colony variants that represent a sub-population of persisters
title_fullStr	Prolonged bacterial lag time results in small colony variants that represent a sub-population of persisters
title_full_unstemmed	Prolonged bacterial lag time results in small colony variants that represent a sub-population of persisters
title_sort	prolonged bacterial lag time results in small colony variants that represent a sub-population of persisters
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/812279b4d2374954bb816ff97c4123c5
work_keys_str_mv	AT clementvulin prolongedbacteriallagtimeresultsinsmallcolonyvariantsthatrepresentasubpopulationofpersisters AT nadjaleimer prolongedbacteriallagtimeresultsinsmallcolonyvariantsthatrepresentasubpopulationofpersisters AT markushuemer prolongedbacteriallagtimeresultsinsmallcolonyvariantsthatrepresentasubpopulationofpersisters AT martinackermann prolongedbacteriallagtimeresultsinsmallcolonyvariantsthatrepresentasubpopulationofpersisters AT anneliesszinkernagel prolongedbacteriallagtimeresultsinsmallcolonyvariantsthatrepresentasubpopulationofpersisters
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Prolonged bacterial lag time results in small colony variants that represent a sub-population of persisters

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