Context specificity of the EMT transcriptional response

It is unclear if a common EMT expression program exists. Here, the authors perform multiplexed single-cell RNA sequencing across 12 EMT time courses and 16 kinase inhibitor screens, and find that EMT transcriptional responses are context specific and EMT is not a single, linear transition.

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Detalles Bibliográficos
Autores principales:	David P. Cook, Barbara C. Vanderhyden
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8126cf3789ae47d38630c96ccbac743f
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spelling	oai:doaj.org-article:8126cf3789ae47d38630c96ccbac743f2021-12-02T15:37:21ZContext specificity of the EMT transcriptional response10.1038/s41467-020-16066-22041-1723https://doaj.org/article/8126cf3789ae47d38630c96ccbac743f2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16066-2https://doaj.org/toc/2041-1723It is unclear if a common EMT expression program exists. Here, the authors perform multiplexed single-cell RNA sequencing across 12 EMT time courses and 16 kinase inhibitor screens, and find that EMT transcriptional responses are context specific and EMT is not a single, linear transition.David P. CookBarbara C. VanderhydenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David P. Cook Barbara C. Vanderhyden Context specificity of the EMT transcriptional response
description	It is unclear if a common EMT expression program exists. Here, the authors perform multiplexed single-cell RNA sequencing across 12 EMT time courses and 16 kinase inhibitor screens, and find that EMT transcriptional responses are context specific and EMT is not a single, linear transition.
format	article
author	David P. Cook Barbara C. Vanderhyden
author_facet	David P. Cook Barbara C. Vanderhyden
author_sort	David P. Cook
title	Context specificity of the EMT transcriptional response
title_short	Context specificity of the EMT transcriptional response
title_full	Context specificity of the EMT transcriptional response
title_fullStr	Context specificity of the EMT transcriptional response
title_full_unstemmed	Context specificity of the EMT transcriptional response
title_sort	context specificity of the emt transcriptional response
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8126cf3789ae47d38630c96ccbac743f
work_keys_str_mv	AT davidpcook contextspecificityoftheemttranscriptionalresponse AT barbaracvanderhyden contextspecificityoftheemttranscriptionalresponse
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Context specificity of the EMT transcriptional response

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