Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development

Production of proliferative follicle cells (FCs) and quiescent escort cells (ECs) by follicle stem cells (FSCs) in adult Drosophila ovaries is regulated by niche signals from anterior (cap cells, ECs) and posterior (polar FCs) sources. Here we show that ECs, FSCs, and FCs develop from common pupal p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Amy Reilein, Helen V Kogan, Rachel Misner, Karen Sophia Park, Daniel Kalderon
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	stem cell development lineage tracing morphogenesis live imaging pupal development oogenesis Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/812a4cc30214498eaee78234c7956ab7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:812a4cc30214498eaee78234c7956ab7
record_format	dspace
spelling	oai:doaj.org-article:812a4cc30214498eaee78234c7956ab72021-12-01T12:15:17ZAdult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development10.7554/eLife.697492050-084Xe69749https://doaj.org/article/812a4cc30214498eaee78234c7956ab72021-09-01T00:00:00Zhttps://elifesciences.org/articles/69749https://doaj.org/toc/2050-084XProduction of proliferative follicle cells (FCs) and quiescent escort cells (ECs) by follicle stem cells (FSCs) in adult Drosophila ovaries is regulated by niche signals from anterior (cap cells, ECs) and posterior (polar FCs) sources. Here we show that ECs, FSCs, and FCs develop from common pupal precursors, with different fates acquired by progressive separation of cells along the AP axis and a graded decline in anterior cell proliferation. ECs, FSCs, and most FCs derive from intermingled cell (IC) precursors interspersed with germline cells. Precursors also accumulate posterior to ICs before engulfing a naked germline cyst projected out of the germarium to form the first egg chamber and posterior polar FC signaling center. Thus, stem and niche cells develop in appropriate numbers and spatial organization through regulated proliferative expansion together with progressive establishment of spatial signaling cues that guide adult cell behavior, rather than through rigid early specification events.Amy ReileinHelen V KoganRachel MisnerKaren Sophia ParkDaniel KalderoneLife Sciences Publications Ltdarticlestem cell developmentlineage tracingmorphogenesislive imagingpupal developmentoogenesisMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stem cell development lineage tracing morphogenesis live imaging pupal development oogenesis Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	stem cell development lineage tracing morphogenesis live imaging pupal development oogenesis Medicine R Science Q Biology (General) QH301-705.5 Amy Reilein Helen V Kogan Rachel Misner Karen Sophia Park Daniel Kalderon Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development
description	Production of proliferative follicle cells (FCs) and quiescent escort cells (ECs) by follicle stem cells (FSCs) in adult Drosophila ovaries is regulated by niche signals from anterior (cap cells, ECs) and posterior (polar FCs) sources. Here we show that ECs, FSCs, and FCs develop from common pupal precursors, with different fates acquired by progressive separation of cells along the AP axis and a graded decline in anterior cell proliferation. ECs, FSCs, and most FCs derive from intermingled cell (IC) precursors interspersed with germline cells. Precursors also accumulate posterior to ICs before engulfing a naked germline cyst projected out of the germarium to form the first egg chamber and posterior polar FC signaling center. Thus, stem and niche cells develop in appropriate numbers and spatial organization through regulated proliferative expansion together with progressive establishment of spatial signaling cues that guide adult cell behavior, rather than through rigid early specification events.
format	article
author	Amy Reilein Helen V Kogan Rachel Misner Karen Sophia Park Daniel Kalderon
author_facet	Amy Reilein Helen V Kogan Rachel Misner Karen Sophia Park Daniel Kalderon
author_sort	Amy Reilein
title	Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development
title_short	Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development
title_full	Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development
title_fullStr	Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development
title_full_unstemmed	Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development
title_sort	adult stem cells and niche cells segregate gradually from common precursors that build the adult drosophila ovary during pupal development
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/812a4cc30214498eaee78234c7956ab7
work_keys_str_mv	AT amyreilein adultstemcellsandnichecellssegregategraduallyfromcommonprecursorsthatbuildtheadultdrosophilaovaryduringpupaldevelopment AT helenvkogan adultstemcellsandnichecellssegregategraduallyfromcommonprecursorsthatbuildtheadultdrosophilaovaryduringpupaldevelopment AT rachelmisner adultstemcellsandnichecellssegregategraduallyfromcommonprecursorsthatbuildtheadultdrosophilaovaryduringpupaldevelopment AT karensophiapark adultstemcellsandnichecellssegregategraduallyfromcommonprecursorsthatbuildtheadultdrosophilaovaryduringpupaldevelopment AT danielkalderon adultstemcellsandnichecellssegregategraduallyfromcommonprecursorsthatbuildtheadultdrosophilaovaryduringpupaldevelopment
_version_	1718405183330844672

Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development

Ejemplares similares