Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4

Neisseria meningitidis bacteria bind to host proteins CD147 and β2-adrenergic receptor on the surface of endothelial cells. Here, Maïssa et al. show that the two proteins interact with each other forming clusters that increase the binding strength of the bacteria to endothelial cells.

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Autores principales:	Nawal Maïssa, Valentina Covarelli, Sébastien Janel, Beatrice Durel, Nandi Simpson, Sandra C. Bernard, Liliana Pardo-Lopez, Haniaa Bouzinba-Ségard, Camille Faure, Mark G.H. Scott, Mathieu Coureuil, Philippe C. Morand, Frank Lafont, Xavier Nassif, Stefano Marullo, Sandrine Bourdoulous
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/812ccd1878054e24ab2fafea122fa20e
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spelling	oai:doaj.org-article:812ccd1878054e24ab2fafea122fa20e2021-12-02T15:39:06ZStrength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-410.1038/ncomms157642041-1723https://doaj.org/article/812ccd1878054e24ab2fafea122fa20e2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15764https://doaj.org/toc/2041-1723Neisseria meningitidis bacteria bind to host proteins CD147 and β2-adrenergic receptor on the surface of endothelial cells. Here, Maïssa et al. show that the two proteins interact with each other forming clusters that increase the binding strength of the bacteria to endothelial cells.Nawal MaïssaValentina CovarelliSébastien JanelBeatrice DurelNandi SimpsonSandra C. BernardLiliana Pardo-LopezHaniaa Bouzinba-SégardCamille FaureMark G.H. ScottMathieu CoureuilPhilippe C. MorandFrank LafontXavier NassifStefano MarulloSandrine BourdoulousNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nawal Maïssa Valentina Covarelli Sébastien Janel Beatrice Durel Nandi Simpson Sandra C. Bernard Liliana Pardo-Lopez Haniaa Bouzinba-Ségard Camille Faure Mark G.H. Scott Mathieu Coureuil Philippe C. Morand Frank Lafont Xavier Nassif Stefano Marullo Sandrine Bourdoulous Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4
description	Neisseria meningitidis bacteria bind to host proteins CD147 and β2-adrenergic receptor on the surface of endothelial cells. Here, Maïssa et al. show that the two proteins interact with each other forming clusters that increase the binding strength of the bacteria to endothelial cells.
format	article
author	Nawal Maïssa Valentina Covarelli Sébastien Janel Beatrice Durel Nandi Simpson Sandra C. Bernard Liliana Pardo-Lopez Haniaa Bouzinba-Ségard Camille Faure Mark G.H. Scott Mathieu Coureuil Philippe C. Morand Frank Lafont Xavier Nassif Stefano Marullo Sandrine Bourdoulous
author_facet	Nawal Maïssa Valentina Covarelli Sébastien Janel Beatrice Durel Nandi Simpson Sandra C. Bernard Liliana Pardo-Lopez Haniaa Bouzinba-Ségard Camille Faure Mark G.H. Scott Mathieu Coureuil Philippe C. Morand Frank Lafont Xavier Nassif Stefano Marullo Sandrine Bourdoulous
author_sort	Nawal Maïssa
title	Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4
title_short	Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4
title_full	Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4
title_fullStr	Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4
title_full_unstemmed	Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4
title_sort	strength of neisseria meningitidis binding to endothelial cells requires highly-ordered cd147/β2-adrenoceptor clusters assembled by alpha-actinin-4
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/812ccd1878054e24ab2fafea122fa20e
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Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4

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