A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia
Apelin and AVP have opposing effects water balance in humans and rodents. Here, the authors report that a metabolically stable apelin-17 analog, by acting at the kidney level, reduces AVP-induced antidiuresis and improves hyponatremia in rodents, demonstrating a potential approach for treating water...
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Nature Portfolio
2021
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oai:doaj.org-article:813075a60acd4a2aae6dfe98df5633102021-12-02T15:22:39ZA metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia10.1038/s41467-020-20560-y2041-1723https://doaj.org/article/813075a60acd4a2aae6dfe98df5633102021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20560-yhttps://doaj.org/toc/2041-1723Apelin and AVP have opposing effects water balance in humans and rodents. Here, the authors report that a metabolically stable apelin-17 analog, by acting at the kidney level, reduces AVP-induced antidiuresis and improves hyponatremia in rodents, demonstrating a potential approach for treating water metabolism disorders.Adrien FlahaultPierre-Emmanuel Girault-SotiasMathilde KeckRodrigo Alvear-PerezNadia De MotaLucie EstéoulleSridévi M. RamanoudjameXavier IturriozDominique BonnetCatherine Llorens-CortesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Adrien Flahault Pierre-Emmanuel Girault-Sotias Mathilde Keck Rodrigo Alvear-Perez Nadia De Mota Lucie Estéoulle Sridévi M. Ramanoudjame Xavier Iturrioz Dominique Bonnet Catherine Llorens-Cortes A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia |
| description |
Apelin and AVP have opposing effects water balance in humans and rodents. Here, the authors report that a metabolically stable apelin-17 analog, by acting at the kidney level, reduces AVP-induced antidiuresis and improves hyponatremia in rodents, demonstrating a potential approach for treating water metabolism disorders. |
| format |
article |
| author |
Adrien Flahault Pierre-Emmanuel Girault-Sotias Mathilde Keck Rodrigo Alvear-Perez Nadia De Mota Lucie Estéoulle Sridévi M. Ramanoudjame Xavier Iturrioz Dominique Bonnet Catherine Llorens-Cortes |
| author_facet |
Adrien Flahault Pierre-Emmanuel Girault-Sotias Mathilde Keck Rodrigo Alvear-Perez Nadia De Mota Lucie Estéoulle Sridévi M. Ramanoudjame Xavier Iturrioz Dominique Bonnet Catherine Llorens-Cortes |
| author_sort |
Adrien Flahault |
| title |
A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia |
| title_short |
A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia |
| title_full |
A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia |
| title_fullStr |
A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia |
| title_full_unstemmed |
A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia |
| title_sort |
metabolically stable apelin-17 analog decreases avp-induced antidiuresis and improves hyponatremia |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/813075a60acd4a2aae6dfe98df563310 |
| work_keys_str_mv |
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1718387389469032448 |