KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect

Kynurenic acid (KYNA) is an endogenous neuroprotective agent of increasing importance. Several derivatives have already been synthesized, bearing an abundance of functional groups attached to the main skeleton in different positions. Several of these compounds have already been tested in biological...

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Autores principales:	Bálint Lőrinczi, István Szatmári
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	kynurenic acid modified hydroxyquinolines Conrad–Limpach reaction neuroprotection modified Mannich reaction Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/813664015e134dd785086567adaecee0
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spelling	oai:doaj.org-article:813664015e134dd785086567adaecee02021-11-11T17:21:00ZKYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect10.3390/ijms2221119351422-00671661-6596https://doaj.org/article/813664015e134dd785086567adaecee02021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11935https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Kynurenic acid (KYNA) is an endogenous neuroprotective agent of increasing importance. Several derivatives have already been synthesized, bearing an abundance of functional groups attached to the main skeleton in different positions. Several of these compounds have already been tested in biological evaluations, with several of them targeting the same receptors and biological effects as KYNA. However, these modified compounds build upon the unmodified KYNA skeleton leaving a possible route for the synthesis of new, potentially neuroprotective derivatives with heteroatom-containing ring systems. The aim of this review is to summarize the syntheses of KYNA derivatives with altered skeletons and to pinpoint an appealing transformation for future medicinal lead molecules.Bálint LőrincziIstván SzatmáriMDPI AGarticlekynurenic acidmodified hydroxyquinolinesConrad–Limpach reactionneuroprotectionmodified Mannich reactionBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11935, p 11935 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	kynurenic acid modified hydroxyquinolines Conrad–Limpach reaction neuroprotection modified Mannich reaction Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	kynurenic acid modified hydroxyquinolines Conrad–Limpach reaction neuroprotection modified Mannich reaction Biology (General) QH301-705.5 Chemistry QD1-999 Bálint Lőrinczi István Szatmári KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect
description	Kynurenic acid (KYNA) is an endogenous neuroprotective agent of increasing importance. Several derivatives have already been synthesized, bearing an abundance of functional groups attached to the main skeleton in different positions. Several of these compounds have already been tested in biological evaluations, with several of them targeting the same receptors and biological effects as KYNA. However, these modified compounds build upon the unmodified KYNA skeleton leaving a possible route for the synthesis of new, potentially neuroprotective derivatives with heteroatom-containing ring systems. The aim of this review is to summarize the syntheses of KYNA derivatives with altered skeletons and to pinpoint an appealing transformation for future medicinal lead molecules.
format	article
author	Bálint Lőrinczi István Szatmári
author_facet	Bálint Lőrinczi István Szatmári
author_sort	Bálint Lőrinczi
title	KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect
title_short	KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect
title_full	KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect
title_fullStr	KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect
title_full_unstemmed	KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect
title_sort	kyna derivatives with modified skeleton; hydroxyquinolines with potential neuroprotective effect
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/813664015e134dd785086567adaecee0
work_keys_str_mv	AT balintlorinczi kynaderivativeswithmodifiedskeletonhydroxyquinolineswithpotentialneuroprotectiveeffect AT istvanszatmari kynaderivativeswithmodifiedskeletonhydroxyquinolineswithpotentialneuroprotectiveeffect
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KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect

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