Housing quality and behavior affect brain health and anxiety in healthy Japanese adults

Abstract Countless studies in animals have shown how housing environments and behaviors can significantly affect anxiety and brain health, giving valuable insight as to whether this is applicable in the human context. The relationship between housing, behavior, brain health, and mental wellbeing in...

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Autores principales:	Juan Cesar D. Pineda, Keisuke Kokubun, Toshiharu Ikaga, Yoshinori Yamakawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/813871ebe46b418c9bd3ed6ad7871f3c
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spelling	oai:doaj.org-article:813871ebe46b418c9bd3ed6ad7871f3c2021-12-02T17:52:25ZHousing quality and behavior affect brain health and anxiety in healthy Japanese adults10.1038/s41598-021-91363-42045-2322https://doaj.org/article/813871ebe46b418c9bd3ed6ad7871f3c2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91363-4https://doaj.org/toc/2045-2322Abstract Countless studies in animals have shown how housing environments and behaviors can significantly affect anxiety and brain health, giving valuable insight as to whether this is applicable in the human context. The relationship between housing, behavior, brain health, and mental wellbeing in humans remains poorly understood. We therefore explored the interaction of housing quality, weekend/holiday sedentary behavior, brain structure, and anxiety in healthy Japanese adults. Whole-brain structural magnetic resonance imaging (MRI) methods based on gray matter volume and fractional anisotropy were used as markers for brain health. Correlation tests were conducted, and then adjusted for multiple comparisons using the False Discovery Rate method. Housing quality and weekend/holiday sedentary behavior were associated with fractional anisotropy, but not with gray matter volume. Fractional anisotropy showed significant associations with anxiety. Lastly, both weekend/holiday sedentary behavior and housing quality were indirectly associated with anxiety through fractional anisotropy. These results add to the limited evidence surrounding the relationship among housing, behavior, and the brain. Furthermore, these results show that behavior and housing qualities can have an indirect impact on anxiety through neurobiological markers such as fractional anisotropy.Juan Cesar D. PinedaKeisuke KokubunToshiharu IkagaYoshinori YamakawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan Cesar D. Pineda Keisuke Kokubun Toshiharu Ikaga Yoshinori Yamakawa Housing quality and behavior affect brain health and anxiety in healthy Japanese adults
description	Abstract Countless studies in animals have shown how housing environments and behaviors can significantly affect anxiety and brain health, giving valuable insight as to whether this is applicable in the human context. The relationship between housing, behavior, brain health, and mental wellbeing in humans remains poorly understood. We therefore explored the interaction of housing quality, weekend/holiday sedentary behavior, brain structure, and anxiety in healthy Japanese adults. Whole-brain structural magnetic resonance imaging (MRI) methods based on gray matter volume and fractional anisotropy were used as markers for brain health. Correlation tests were conducted, and then adjusted for multiple comparisons using the False Discovery Rate method. Housing quality and weekend/holiday sedentary behavior were associated with fractional anisotropy, but not with gray matter volume. Fractional anisotropy showed significant associations with anxiety. Lastly, both weekend/holiday sedentary behavior and housing quality were indirectly associated with anxiety through fractional anisotropy. These results add to the limited evidence surrounding the relationship among housing, behavior, and the brain. Furthermore, these results show that behavior and housing qualities can have an indirect impact on anxiety through neurobiological markers such as fractional anisotropy.
format	article
author	Juan Cesar D. Pineda Keisuke Kokubun Toshiharu Ikaga Yoshinori Yamakawa
author_facet	Juan Cesar D. Pineda Keisuke Kokubun Toshiharu Ikaga Yoshinori Yamakawa
author_sort	Juan Cesar D. Pineda
title	Housing quality and behavior affect brain health and anxiety in healthy Japanese adults
title_short	Housing quality and behavior affect brain health and anxiety in healthy Japanese adults
title_full	Housing quality and behavior affect brain health and anxiety in healthy Japanese adults
title_fullStr	Housing quality and behavior affect brain health and anxiety in healthy Japanese adults
title_full_unstemmed	Housing quality and behavior affect brain health and anxiety in healthy Japanese adults
title_sort	housing quality and behavior affect brain health and anxiety in healthy japanese adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/813871ebe46b418c9bd3ed6ad7871f3c
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_version_	1718379235326820352

Housing quality and behavior affect brain health and anxiety in healthy Japanese adults

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