mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion

Antibody production in plasma cells involves the unfold protein response (UPR), but how this is regulated is not clear. Here the authors show that mTORC1 signalling but not Xbp1-mediated transcription regulation in activated B cells is important for the induction of a UPR-related transcriptome that...

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Autores principales:	Brian T. Gaudette, Derek D. Jones, Alexandra Bortnick, Yair Argon, David Allman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81396dc5ad0c422c90459afebbba9095
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spelling	oai:doaj.org-article:81396dc5ad0c422c90459afebbba90952021-12-02T14:42:32ZmTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion10.1038/s41467-019-14032-12041-1723https://doaj.org/article/81396dc5ad0c422c90459afebbba90952020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14032-1https://doaj.org/toc/2041-1723Antibody production in plasma cells involves the unfold protein response (UPR), but how this is regulated is not clear. Here the authors show that mTORC1 signalling but not Xbp1-mediated transcription regulation in activated B cells is important for the induction of a UPR-related transcriptome that precedes full plasma cell functions.Brian T. GaudetteDerek D. JonesAlexandra BortnickYair ArgonDavid AllmanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brian T. Gaudette Derek D. Jones Alexandra Bortnick Yair Argon David Allman mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion
description	Antibody production in plasma cells involves the unfold protein response (UPR), but how this is regulated is not clear. Here the authors show that mTORC1 signalling but not Xbp1-mediated transcription regulation in activated B cells is important for the induction of a UPR-related transcriptome that precedes full plasma cell functions.
format	article
author	Brian T. Gaudette Derek D. Jones Alexandra Bortnick Yair Argon David Allman
author_facet	Brian T. Gaudette Derek D. Jones Alexandra Bortnick Yair Argon David Allman
author_sort	Brian T. Gaudette
title	mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion
title_short	mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion
title_full	mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion
title_fullStr	mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion
title_full_unstemmed	mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion
title_sort	mtorc1 coordinates an immediate unfolded protein response-related transcriptome in activated b cells preceding antibody secretion
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/81396dc5ad0c422c90459afebbba9095
work_keys_str_mv	AT briantgaudette mtorc1coordinatesanimmediateunfoldedproteinresponserelatedtranscriptomeinactivatedbcellsprecedingantibodysecretion AT derekdjones mtorc1coordinatesanimmediateunfoldedproteinresponserelatedtranscriptomeinactivatedbcellsprecedingantibodysecretion AT alexandrabortnick mtorc1coordinatesanimmediateunfoldedproteinresponserelatedtranscriptomeinactivatedbcellsprecedingantibodysecretion AT yairargon mtorc1coordinatesanimmediateunfoldedproteinresponserelatedtranscriptomeinactivatedbcellsprecedingantibodysecretion AT davidallman mtorc1coordinatesanimmediateunfoldedproteinresponserelatedtranscriptomeinactivatedbcellsprecedingantibodysecretion
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mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion

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