Solid dispersions in the form of electrospun core-sheath nanofibers

Deng-GuangYu1, Li-Min Zhu2, Christopher J Branford-White3, Jun-He Yang1, Xia Wang1, Ying Li1, Wei Qian11School of Materials Science and Engineering, University of Shanghai for Science and Technology; 2College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, People&...

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Autores principales:	Yu DG, Zhu LM, Branford-White CJ, Yang JH, Wang X, Li Y, Qian W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/813c2c11310c49b69de31a44195658df
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spelling	oai:doaj.org-article:813c2c11310c49b69de31a44195658df2021-12-02T02:10:27ZSolid dispersions in the form of electrospun core-sheath nanofibers1176-91141178-2013https://doaj.org/article/813c2c11310c49b69de31a44195658df2011-12-01T00:00:00Zhttp://www.dovepress.com/solid-dispersions-in-the-form-of-electrospun-core-sheath-nanofibers-a8863https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Deng-GuangYu1, Li-Min Zhu2, Christopher J Branford-White3, Jun-He Yang1, Xia Wang1, Ying Li1, Wei Qian11School of Materials Science and Engineering, University of Shanghai for Science and Technology; 2College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, People&#39;s Republic of China; 3Faculty of Life Sciences, London Metropolitan University, London, United KingdomBackground: The objective of this investigation was to develop a new type of solid dispersion in the form of core-sheath nanofibers using coaxial electrospinning for poorly water-soluble drugs. Different functional ingredients can be placed in various parts of core-sheath nanofibers to improve synergistically the dissolution and permeation properties of encapsulated drugs and to enable drugs to exert their actions.Methods: Using acyclovir as a model drug, polyvinylpyrrolidone as the hydrophilic filament-forming polymer matrix, sodium dodecyl sulfate as a transmembrane enhancer, and sucralose as a sweetener, core-sheath nanofibers were successfully prepared, with the sheath part consisting of polyvinylpyrrolidone, sodium dodecyl sulfate, and sucralose, and the core part composed of polyvinylpyrrolidone and acyclovir.Results: The core-sheath nanofibers had an average diameter of 410 &plusmn; 94 nm with a uniform structure and smooth surface. Differential scanning calorimetry and x-ray diffraction results demonstrated that acyclovir, sodium dodecyl sulfate, and sucralose were well distributed in the polyvinylpyrrolidone matrix in an amorphous state due to favoring of second-order interactions. In vitro dissolution and permeation studies showed that the core-sheath nanofiber solid dispersions could rapidly release acyclovir within one minute, with an over six-fold increased permeation rate across the sublingual mucosa compared with that of crude acyclovir particles.Conclusion: The study reported here provides an example of the systematic design, preparation, characterization, and application of a novel type of solid dispersion consisting of multiple components and structural characteristics.Keywords: core-sheath nanofibers, solid dispersion, coaxial electrospinning, poorly water-soluble drug, dissolution, permeationYu DGZhu LMBranford-White CJYang JHWang XLi YQian WDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 3271-3280 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Yu DG Zhu LM Branford-White CJ Yang JH Wang X Li Y Qian W Solid dispersions in the form of electrospun core-sheath nanofibers
description	Deng-GuangYu1, Li-Min Zhu2, Christopher J Branford-White3, Jun-He Yang1, Xia Wang1, Ying Li1, Wei Qian11School of Materials Science and Engineering, University of Shanghai for Science and Technology; 2College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, People&#39;s Republic of China; 3Faculty of Life Sciences, London Metropolitan University, London, United KingdomBackground: The objective of this investigation was to develop a new type of solid dispersion in the form of core-sheath nanofibers using coaxial electrospinning for poorly water-soluble drugs. Different functional ingredients can be placed in various parts of core-sheath nanofibers to improve synergistically the dissolution and permeation properties of encapsulated drugs and to enable drugs to exert their actions.Methods: Using acyclovir as a model drug, polyvinylpyrrolidone as the hydrophilic filament-forming polymer matrix, sodium dodecyl sulfate as a transmembrane enhancer, and sucralose as a sweetener, core-sheath nanofibers were successfully prepared, with the sheath part consisting of polyvinylpyrrolidone, sodium dodecyl sulfate, and sucralose, and the core part composed of polyvinylpyrrolidone and acyclovir.Results: The core-sheath nanofibers had an average diameter of 410 &plusmn; 94 nm with a uniform structure and smooth surface. Differential scanning calorimetry and x-ray diffraction results demonstrated that acyclovir, sodium dodecyl sulfate, and sucralose were well distributed in the polyvinylpyrrolidone matrix in an amorphous state due to favoring of second-order interactions. In vitro dissolution and permeation studies showed that the core-sheath nanofiber solid dispersions could rapidly release acyclovir within one minute, with an over six-fold increased permeation rate across the sublingual mucosa compared with that of crude acyclovir particles.Conclusion: The study reported here provides an example of the systematic design, preparation, characterization, and application of a novel type of solid dispersion consisting of multiple components and structural characteristics.Keywords: core-sheath nanofibers, solid dispersion, coaxial electrospinning, poorly water-soluble drug, dissolution, permeation
format	article
author	Yu DG Zhu LM Branford-White CJ Yang JH Wang X Li Y Qian W
author_facet	Yu DG Zhu LM Branford-White CJ Yang JH Wang X Li Y Qian W
author_sort	Yu DG
title	Solid dispersions in the form of electrospun core-sheath nanofibers
title_short	Solid dispersions in the form of electrospun core-sheath nanofibers
title_full	Solid dispersions in the form of electrospun core-sheath nanofibers
title_fullStr	Solid dispersions in the form of electrospun core-sheath nanofibers
title_full_unstemmed	Solid dispersions in the form of electrospun core-sheath nanofibers
title_sort	solid dispersions in the form of electrospun core-sheath nanofibers
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/813c2c11310c49b69de31a44195658df
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Solid dispersions in the form of electrospun core-sheath nanofibers

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