Population receptive fields of human primary visual cortex organised as DC-balanced bandpass filters

Abstract The response to visual stimulation of population receptive fields (pRF) in the human visual cortex has been modelled with a Difference of Gaussians model, yet many aspects of their organisation remain poorly understood. Here, we examined the mathematical basis and signal-processing properti...

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Autores principales:	Daniel Gramm Kristensen, Kristian Sandberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/81440504c86e481fb3491c88f0cc4dbf
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spelling	oai:doaj.org-article:81440504c86e481fb3491c88f0cc4dbf2021-11-21T12:24:14ZPopulation receptive fields of human primary visual cortex organised as DC-balanced bandpass filters10.1038/s41598-021-01891-22045-2322https://doaj.org/article/81440504c86e481fb3491c88f0cc4dbf2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01891-2https://doaj.org/toc/2045-2322Abstract The response to visual stimulation of population receptive fields (pRF) in the human visual cortex has been modelled with a Difference of Gaussians model, yet many aspects of their organisation remain poorly understood. Here, we examined the mathematical basis and signal-processing properties of this model and argue that the DC-balanced Difference of Gaussians (DoG) holds a number of advantages over a DC-biased DoG. Through functional magnetic resonance imaging (fMRI) pRF mapping, we compared performance of DC-balanced and DC-biased models in human primary visual cortex and found that when model complexity is taken into account, the DC-balanced model is preferred. Finally, we present evidence indicating that the BOLD signal DC offset contains information related to the processing of visual stimuli. Taken together, the results indicate that V1 pRFs are at least frequently organised in the exact constellation that allows them to function as bandpass filters, which makes the separation of stimulus contrast and luminance possible. We further speculate that if the DoG models stimulus contrast, the DC offset may reflect stimulus luminance. These findings suggest that it may be possible to separate contrast and luminance processing in fMRI experiments and this could lead to new insights on the haemodynamic response.Daniel Gramm KristensenKristian SandbergNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel Gramm Kristensen Kristian Sandberg Population receptive fields of human primary visual cortex organised as DC-balanced bandpass filters
description	Abstract The response to visual stimulation of population receptive fields (pRF) in the human visual cortex has been modelled with a Difference of Gaussians model, yet many aspects of their organisation remain poorly understood. Here, we examined the mathematical basis and signal-processing properties of this model and argue that the DC-balanced Difference of Gaussians (DoG) holds a number of advantages over a DC-biased DoG. Through functional magnetic resonance imaging (fMRI) pRF mapping, we compared performance of DC-balanced and DC-biased models in human primary visual cortex and found that when model complexity is taken into account, the DC-balanced model is preferred. Finally, we present evidence indicating that the BOLD signal DC offset contains information related to the processing of visual stimuli. Taken together, the results indicate that V1 pRFs are at least frequently organised in the exact constellation that allows them to function as bandpass filters, which makes the separation of stimulus contrast and luminance possible. We further speculate that if the DoG models stimulus contrast, the DC offset may reflect stimulus luminance. These findings suggest that it may be possible to separate contrast and luminance processing in fMRI experiments and this could lead to new insights on the haemodynamic response.
format	article
author	Daniel Gramm Kristensen Kristian Sandberg
author_facet	Daniel Gramm Kristensen Kristian Sandberg
author_sort	Daniel Gramm Kristensen
title	Population receptive fields of human primary visual cortex organised as DC-balanced bandpass filters
title_short	Population receptive fields of human primary visual cortex organised as DC-balanced bandpass filters
title_full	Population receptive fields of human primary visual cortex organised as DC-balanced bandpass filters
title_fullStr	Population receptive fields of human primary visual cortex organised as DC-balanced bandpass filters
title_full_unstemmed	Population receptive fields of human primary visual cortex organised as DC-balanced bandpass filters
title_sort	population receptive fields of human primary visual cortex organised as dc-balanced bandpass filters
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/81440504c86e481fb3491c88f0cc4dbf
work_keys_str_mv	AT danielgrammkristensen populationreceptivefieldsofhumanprimaryvisualcortexorganisedasdcbalancedbandpassfilters AT kristiansandberg populationreceptivefieldsofhumanprimaryvisualcortexorganisedasdcbalancedbandpassfilters
_version_	1718419016414920704

Population receptive fields of human primary visual cortex organised as DC-balanced bandpass filters

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