Orexin-A in Patients With Lewy Body Disease: A Systematic Review and Meta-Analysis

BackgroundAbnormal orexin-A levels in cerebrospinal fluid (CSF) have been identified in Alzheimer’s disease (AD) and other neurodegenerative diseases. However, few studies have focused on Lewy body disease (LBD) and often with debatable outcomes. Thus, we performed this systematic review and meta-an...

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Autores principales:	Jinghuan Gan, Zhichao Chen, Jiuyan Han, Lingyun Ma, Shuai Liu, Xiao-Dan Wang, Yong Ji
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	orexin-A (hypocretin-1) Lewy body disease Parkinson’s disease excessive daytime sleepiness systematic review meta-analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/814850451241488e87de83b476a1c9ae
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spelling	oai:doaj.org-article:814850451241488e87de83b476a1c9ae2021-11-17T06:13:52ZOrexin-A in Patients With Lewy Body Disease: A Systematic Review and Meta-Analysis1664-239210.3389/fendo.2021.765701https://doaj.org/article/814850451241488e87de83b476a1c9ae2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.765701/fullhttps://doaj.org/toc/1664-2392BackgroundAbnormal orexin-A levels in cerebrospinal fluid (CSF) have been identified in Alzheimer’s disease (AD) and other neurodegenerative diseases. However, few studies have focused on Lewy body disease (LBD) and often with debatable outcomes. Thus, we performed this systematic review and meta-analysis to investigate orexin-A levels in LBD by incorporating data from different studies.MethodsWe gathered studies comparing orexin-A levels in patients with LBD and controls (including healthy controls and other dementia subtypes). In the initial search, 117 relevant articles were identified. After a selection process, seven studies, conducted in Japan, USA, Spain, Switzerland, France, Italy, and Netherlands, were chosen.ResultsIn total, 179 patients with LBD and 253 controls were included. Patients with LBD had significantly lower mean orexin-A CSF levels when compared with patients with AD [standard mean difference (SMD): −0.35, 95% confidence interval (CI): −0.70 to −0.00, Z = 1.96, P = 0.05], whereas mean orexin-A levels were significantly higher when compared with patients with frontotemporal lobar degeneration (FTLD) (SMD: 0.61, 95% CI: 0.23–0.99, Z = 3.12, P = 0.002). Orexin-A CSF levels in LBD patients were approximately equal to levels in healthy elderly individuals, whereas they were significantly decreased in LBD patients with excessive daytime sleepiness (EDS) (SMD: -0.15, 95% CI: -0.59 to 0.29, Z = 0.67, P = 0.50).ConclusionsWe showed that orexin-A levels in patients with LBD were not very different from those in normal elderly individuals, whereas they were lower than those in AD patients and higher than those in FTLD patients. The influence of hypersomnia on orexin-A levels should be carefully interpreted.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42021265900.Jinghuan GanZhichao ChenJiuyan HanLingyun MaShuai LiuXiao-Dan WangYong JiYong JiFrontiers Media S.A.articleorexin-A (hypocretin-1)Lewy body diseaseParkinson’s diseaseexcessive daytime sleepinesssystematic reviewmeta-analysisDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	orexin-A (hypocretin-1) Lewy body disease Parkinson’s disease excessive daytime sleepiness systematic review meta-analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	orexin-A (hypocretin-1) Lewy body disease Parkinson’s disease excessive daytime sleepiness systematic review meta-analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665 Jinghuan Gan Zhichao Chen Jiuyan Han Lingyun Ma Shuai Liu Xiao-Dan Wang Yong Ji Yong Ji Orexin-A in Patients With Lewy Body Disease: A Systematic Review and Meta-Analysis
description	BackgroundAbnormal orexin-A levels in cerebrospinal fluid (CSF) have been identified in Alzheimer’s disease (AD) and other neurodegenerative diseases. However, few studies have focused on Lewy body disease (LBD) and often with debatable outcomes. Thus, we performed this systematic review and meta-analysis to investigate orexin-A levels in LBD by incorporating data from different studies.MethodsWe gathered studies comparing orexin-A levels in patients with LBD and controls (including healthy controls and other dementia subtypes). In the initial search, 117 relevant articles were identified. After a selection process, seven studies, conducted in Japan, USA, Spain, Switzerland, France, Italy, and Netherlands, were chosen.ResultsIn total, 179 patients with LBD and 253 controls were included. Patients with LBD had significantly lower mean orexin-A CSF levels when compared with patients with AD [standard mean difference (SMD): −0.35, 95% confidence interval (CI): −0.70 to −0.00, Z = 1.96, P = 0.05], whereas mean orexin-A levels were significantly higher when compared with patients with frontotemporal lobar degeneration (FTLD) (SMD: 0.61, 95% CI: 0.23–0.99, Z = 3.12, P = 0.002). Orexin-A CSF levels in LBD patients were approximately equal to levels in healthy elderly individuals, whereas they were significantly decreased in LBD patients with excessive daytime sleepiness (EDS) (SMD: -0.15, 95% CI: -0.59 to 0.29, Z = 0.67, P = 0.50).ConclusionsWe showed that orexin-A levels in patients with LBD were not very different from those in normal elderly individuals, whereas they were lower than those in AD patients and higher than those in FTLD patients. The influence of hypersomnia on orexin-A levels should be carefully interpreted.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42021265900.
format	article
author	Jinghuan Gan Zhichao Chen Jiuyan Han Lingyun Ma Shuai Liu Xiao-Dan Wang Yong Ji Yong Ji
author_facet	Jinghuan Gan Zhichao Chen Jiuyan Han Lingyun Ma Shuai Liu Xiao-Dan Wang Yong Ji Yong Ji
author_sort	Jinghuan Gan
title	Orexin-A in Patients With Lewy Body Disease: A Systematic Review and Meta-Analysis
title_short	Orexin-A in Patients With Lewy Body Disease: A Systematic Review and Meta-Analysis
title_full	Orexin-A in Patients With Lewy Body Disease: A Systematic Review and Meta-Analysis
title_fullStr	Orexin-A in Patients With Lewy Body Disease: A Systematic Review and Meta-Analysis
title_full_unstemmed	Orexin-A in Patients With Lewy Body Disease: A Systematic Review and Meta-Analysis
title_sort	orexin-a in patients with lewy body disease: a systematic review and meta-analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/814850451241488e87de83b476a1c9ae
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Orexin-A in Patients With Lewy Body Disease: A Systematic Review and Meta-Analysis

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