Overexpression of small nucleolar RNA SNORD1C is associated with unfavorable outcome in colorectal cancer

Colorectal cancer (CRC) is the second most incident cancer and third leading cause of cancer-related mortality worldwide. Small nucleolar RNAs (snoRNAs) are small non-coding RNAs located in the nucleoli of cells, and play key roles in multiple cancers. However, the role of serum snoRNAs in CRC remai...

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Autores principales:	Yonghui Liu, Chengwen Zhao, Jing Sun, Guihua Wang, Shaoqing Ju, Chen Qian, Xudong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	small nucleolar rnas snord1c colorectal cancer biomarker diagnosis Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/8148c11dfa92462fba0f8602acc7e39a
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spelling	oai:doaj.org-article:8148c11dfa92462fba0f8602acc7e39a2021-11-04T15:51:53ZOverexpression of small nucleolar RNA SNORD1C is associated with unfavorable outcome in colorectal cancer2165-59792165-598710.1080/21655979.2021.1990194https://doaj.org/article/8148c11dfa92462fba0f8602acc7e39a2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1990194https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Colorectal cancer (CRC) is the second most incident cancer and third leading cause of cancer-related mortality worldwide. Small nucleolar RNAs (snoRNAs) are small non-coding RNAs located in the nucleoli of cells, and play key roles in multiple cancers. However, the role of serum snoRNAs in CRC remains unknown. We analyzed the expression of the snoRNA SNORD1C in the serum of patients with CRC using quantitative real-time polymerase chain reaction (qRT-PCR) (n = 122). The receiver operating characteristic (ROC) curves were estimated, and the area under the ROC curve (AUC) was calculated. Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) analysis of co-expressed genes was performed using the database for annotation, visualization, and integrated discovery (DAVID), and visualized by R language. The results showed that the expression of SNORD1C in patients with CRC (n = 122) was significantly higher than that in normal individuals (n = 50) and patients with benign colorectal disease (n = 33) (P < 0.05). The overexpression of serum SNORD1C was related to poor tissue differentiation and high carcinoembryonic antigen (CEA) levels (P < 0.05). In the ROC curve analysis, SNORD1C serum expression combined with CEA offered better predictive value for the diagnosis of CRC (AUC = 0.838) compared with SNORD1C (AUC = 0.748) or CEA (AUC = 0.715) alone. High expression of SNORD1C was found to be closely associated with prognosis and unfavorable outcomes in patient with CRC. Therefore, serum SNORD1C may be a noninvasive tumor biomarker for diagnosis of CRC.Yonghui LiuChengwen ZhaoJing SunGuihua WangShaoqing JuChen QianXudong WangTaylor & Francis Grouparticlesmall nucleolar rnassnord1ccolorectal cancerbiomarkerdiagnosisBiotechnologyTP248.13-248.65ENBioengineered, Vol 12, Iss 1, Pp 8943-8952 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	small nucleolar rnas snord1c colorectal cancer biomarker diagnosis Biotechnology TP248.13-248.65
spellingShingle	small nucleolar rnas snord1c colorectal cancer biomarker diagnosis Biotechnology TP248.13-248.65 Yonghui Liu Chengwen Zhao Jing Sun Guihua Wang Shaoqing Ju Chen Qian Xudong Wang Overexpression of small nucleolar RNA SNORD1C is associated with unfavorable outcome in colorectal cancer
description	Colorectal cancer (CRC) is the second most incident cancer and third leading cause of cancer-related mortality worldwide. Small nucleolar RNAs (snoRNAs) are small non-coding RNAs located in the nucleoli of cells, and play key roles in multiple cancers. However, the role of serum snoRNAs in CRC remains unknown. We analyzed the expression of the snoRNA SNORD1C in the serum of patients with CRC using quantitative real-time polymerase chain reaction (qRT-PCR) (n = 122). The receiver operating characteristic (ROC) curves were estimated, and the area under the ROC curve (AUC) was calculated. Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) analysis of co-expressed genes was performed using the database for annotation, visualization, and integrated discovery (DAVID), and visualized by R language. The results showed that the expression of SNORD1C in patients with CRC (n = 122) was significantly higher than that in normal individuals (n = 50) and patients with benign colorectal disease (n = 33) (P < 0.05). The overexpression of serum SNORD1C was related to poor tissue differentiation and high carcinoembryonic antigen (CEA) levels (P < 0.05). In the ROC curve analysis, SNORD1C serum expression combined with CEA offered better predictive value for the diagnosis of CRC (AUC = 0.838) compared with SNORD1C (AUC = 0.748) or CEA (AUC = 0.715) alone. High expression of SNORD1C was found to be closely associated with prognosis and unfavorable outcomes in patient with CRC. Therefore, serum SNORD1C may be a noninvasive tumor biomarker for diagnosis of CRC.
format	article
author	Yonghui Liu Chengwen Zhao Jing Sun Guihua Wang Shaoqing Ju Chen Qian Xudong Wang
author_facet	Yonghui Liu Chengwen Zhao Jing Sun Guihua Wang Shaoqing Ju Chen Qian Xudong Wang
author_sort	Yonghui Liu
title	Overexpression of small nucleolar RNA SNORD1C is associated with unfavorable outcome in colorectal cancer
title_short	Overexpression of small nucleolar RNA SNORD1C is associated with unfavorable outcome in colorectal cancer
title_full	Overexpression of small nucleolar RNA SNORD1C is associated with unfavorable outcome in colorectal cancer
title_fullStr	Overexpression of small nucleolar RNA SNORD1C is associated with unfavorable outcome in colorectal cancer
title_full_unstemmed	Overexpression of small nucleolar RNA SNORD1C is associated with unfavorable outcome in colorectal cancer
title_sort	overexpression of small nucleolar rna snord1c is associated with unfavorable outcome in colorectal cancer
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/8148c11dfa92462fba0f8602acc7e39a
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_version_	1718444723194036224

Overexpression of small nucleolar RNA SNORD1C is associated with unfavorable outcome in colorectal cancer

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