Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance

Tumour microenvironment actively contributes to drug resistance in clinical oncology. Here, the authors show that genotoxic stress induces senescence in human stromal cells, which in turn secrete serine protease inhibitor Kazal type 1 (SPINK1) and promote acquired resistance of cancer cells via EGFR...

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Autores principales:	Fei Chen, Qilai Long, Da Fu, Dexiang Zhu, Yan Ji, Liu Han, Boyi Zhang, Qixia Xu, Bingjie Liu, Yan Li, Shanshan Wu, Chen Yang, Min Qian, Jianmin Xu, Suling Liu, Liu Cao, Y. Eugene Chin, Eric W.-F. Lam, Jean-Philippe Coppé, Yu Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/814d6dc53fea4b498e4d863a03b8fd96
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spelling	oai:doaj.org-article:814d6dc53fea4b498e4d863a03b8fd962021-12-02T15:34:26ZTargeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance10.1038/s41467-018-06860-42041-1723https://doaj.org/article/814d6dc53fea4b498e4d863a03b8fd962018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06860-4https://doaj.org/toc/2041-1723Tumour microenvironment actively contributes to drug resistance in clinical oncology. Here, the authors show that genotoxic stress induces senescence in human stromal cells, which in turn secrete serine protease inhibitor Kazal type 1 (SPINK1) and promote acquired resistance of cancer cells via EGFR-mediated paracrine signaling.Fei ChenQilai LongDa FuDexiang ZhuYan JiLiu HanBoyi ZhangQixia XuBingjie LiuYan LiShanshan WuChen YangMin QianJianmin XuSuling LiuLiu CaoY. Eugene ChinEric W.-F. LamJean-Philippe CoppéYu SunNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fei Chen Qilai Long Da Fu Dexiang Zhu Yan Ji Liu Han Boyi Zhang Qixia Xu Bingjie Liu Yan Li Shanshan Wu Chen Yang Min Qian Jianmin Xu Suling Liu Liu Cao Y. Eugene Chin Eric W.-F. Lam Jean-Philippe Coppé Yu Sun Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance
description	Tumour microenvironment actively contributes to drug resistance in clinical oncology. Here, the authors show that genotoxic stress induces senescence in human stromal cells, which in turn secrete serine protease inhibitor Kazal type 1 (SPINK1) and promote acquired resistance of cancer cells via EGFR-mediated paracrine signaling.
format	article
author	Fei Chen Qilai Long Da Fu Dexiang Zhu Yan Ji Liu Han Boyi Zhang Qixia Xu Bingjie Liu Yan Li Shanshan Wu Chen Yang Min Qian Jianmin Xu Suling Liu Liu Cao Y. Eugene Chin Eric W.-F. Lam Jean-Philippe Coppé Yu Sun
author_facet	Fei Chen Qilai Long Da Fu Dexiang Zhu Yan Ji Liu Han Boyi Zhang Qixia Xu Bingjie Liu Yan Li Shanshan Wu Chen Yang Min Qian Jianmin Xu Suling Liu Liu Cao Y. Eugene Chin Eric W.-F. Lam Jean-Philippe Coppé Yu Sun
author_sort	Fei Chen
title	Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance
title_short	Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance
title_full	Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance
title_fullStr	Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance
title_full_unstemmed	Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance
title_sort	targeting spink1 in the damaged tumour microenvironment alleviates therapeutic resistance
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/814d6dc53fea4b498e4d863a03b8fd96
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Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance

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