Molecular Mechanism of Gas Anesthetics on the Invasion, Metastasis, and Chemosensitivity of Osteosarcoma Cells

Background. Osteosarcoma is one of the most prominent bone cancers which has a predominant occurrence in children and adolescents. This study is focused on determining the effects of treatment of gas anesthetics on invasion, metastasis, and chemosensitivity in the progression of osteosarcoma cells....

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Autores principales:	Qian Zhao, Jianyong Yan, Wen Li, Ye Yang, Lu You, Chenguang Qin
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Computer applications to medicine. Medical informatics R858-859.7
Acceso en línea:	https://doaj.org/article/814d971cf0374db8a4300a3c7507636c
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spelling	oai:doaj.org-article:814d971cf0374db8a4300a3c7507636c2021-11-15T01:19:17ZMolecular Mechanism of Gas Anesthetics on the Invasion, Metastasis, and Chemosensitivity of Osteosarcoma Cells1748-671810.1155/2021/6000385https://doaj.org/article/814d971cf0374db8a4300a3c7507636c2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6000385https://doaj.org/toc/1748-6718Background. Osteosarcoma is one of the most prominent bone cancers which has a predominant occurrence in children and adolescents. This study is focused on determining the effects of treatment of gas anesthetics on invasion, metastasis, and chemosensitivity in the progression of osteosarcoma cells. Material and Methods. The biological effects of the common gas anesthetics—desflurane, isoflurane, and sevoflurane—on osteosarcoma cells were studied and compared. The biological assays were performed for analysis of cell migration and proliferation. Results. Isoflurane and sevoflurane have shown significant inhibition in the osteosarcoma cells at clinically relevant concentrations. Desflurane has shown less potent action on cell migration and inhibition. All three gas anesthetics have shown inhibition in cell proliferation. The effective antiproliferative action was at a clinically significant dose. At low millimolar concentrations, cell apoptosis was moderately affected. Drug combination analysis with chemotherapeutic drugs showed relevant inhibition in cell migration. All three agents showed significant augmentation of chemotherapeutic drugs in suppression and inhibition of inducing apoptosis. The antimigration action is likely to affect the PI3K/AKT pathway and IGF-1. Conclusion. The study demonstrates the proposed mechanisms of gas anesthetics and their differential effects on osteosarcoma cells and their survival, migration, growth, and chemosensitivity.Qian ZhaoJianyong YanWen LiYe YangLu YouChenguang QinHindawi LimitedarticleComputer applications to medicine. Medical informaticsR858-859.7ENComputational and Mathematical Methods in Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Computer applications to medicine. Medical informatics R858-859.7
spellingShingle	Computer applications to medicine. Medical informatics R858-859.7 Qian Zhao Jianyong Yan Wen Li Ye Yang Lu You Chenguang Qin Molecular Mechanism of Gas Anesthetics on the Invasion, Metastasis, and Chemosensitivity of Osteosarcoma Cells
description	Background. Osteosarcoma is one of the most prominent bone cancers which has a predominant occurrence in children and adolescents. This study is focused on determining the effects of treatment of gas anesthetics on invasion, metastasis, and chemosensitivity in the progression of osteosarcoma cells. Material and Methods. The biological effects of the common gas anesthetics—desflurane, isoflurane, and sevoflurane—on osteosarcoma cells were studied and compared. The biological assays were performed for analysis of cell migration and proliferation. Results. Isoflurane and sevoflurane have shown significant inhibition in the osteosarcoma cells at clinically relevant concentrations. Desflurane has shown less potent action on cell migration and inhibition. All three gas anesthetics have shown inhibition in cell proliferation. The effective antiproliferative action was at a clinically significant dose. At low millimolar concentrations, cell apoptosis was moderately affected. Drug combination analysis with chemotherapeutic drugs showed relevant inhibition in cell migration. All three agents showed significant augmentation of chemotherapeutic drugs in suppression and inhibition of inducing apoptosis. The antimigration action is likely to affect the PI3K/AKT pathway and IGF-1. Conclusion. The study demonstrates the proposed mechanisms of gas anesthetics and their differential effects on osteosarcoma cells and their survival, migration, growth, and chemosensitivity.
format	article
author	Qian Zhao Jianyong Yan Wen Li Ye Yang Lu You Chenguang Qin
author_facet	Qian Zhao Jianyong Yan Wen Li Ye Yang Lu You Chenguang Qin
author_sort	Qian Zhao
title	Molecular Mechanism of Gas Anesthetics on the Invasion, Metastasis, and Chemosensitivity of Osteosarcoma Cells
title_short	Molecular Mechanism of Gas Anesthetics on the Invasion, Metastasis, and Chemosensitivity of Osteosarcoma Cells
title_full	Molecular Mechanism of Gas Anesthetics on the Invasion, Metastasis, and Chemosensitivity of Osteosarcoma Cells
title_fullStr	Molecular Mechanism of Gas Anesthetics on the Invasion, Metastasis, and Chemosensitivity of Osteosarcoma Cells
title_full_unstemmed	Molecular Mechanism of Gas Anesthetics on the Invasion, Metastasis, and Chemosensitivity of Osteosarcoma Cells
title_sort	molecular mechanism of gas anesthetics on the invasion, metastasis, and chemosensitivity of osteosarcoma cells
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/814d971cf0374db8a4300a3c7507636c
work_keys_str_mv	AT qianzhao molecularmechanismofgasanestheticsontheinvasionmetastasisandchemosensitivityofosteosarcomacells AT jianyongyan molecularmechanismofgasanestheticsontheinvasionmetastasisandchemosensitivityofosteosarcomacells AT wenli molecularmechanismofgasanestheticsontheinvasionmetastasisandchemosensitivityofosteosarcomacells AT yeyang molecularmechanismofgasanestheticsontheinvasionmetastasisandchemosensitivityofosteosarcomacells AT luyou molecularmechanismofgasanestheticsontheinvasionmetastasisandchemosensitivityofosteosarcomacells AT chenguangqin molecularmechanismofgasanestheticsontheinvasionmetastasisandchemosensitivityofosteosarcomacells
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Molecular Mechanism of Gas Anesthetics on the Invasion, Metastasis, and Chemosensitivity of Osteosarcoma Cells

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