The role of Dermcidin isoform-2 in the occurrence and severity of Diabetes

Abstract Diabetes is now epidemic worldwide. Several hundred-million peoples are presently suffering from this disease with other secondary-disorders. Stress, hypertension, sedentary life-style, carbohydrate/lipid metabolic-disorders due to genetic or environmental factors attributes to type-1 and/o...

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Autores principales:	Suman Bhattacharya, Md. Mobidullah Khan, Chandradipa Ghosh, Sarbashri Bank, Smarajit Maiti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/814f1ff27d0041a081a5ec80c2e36077
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spelling	oai:doaj.org-article:814f1ff27d0041a081a5ec80c2e360772021-12-02T15:05:08ZThe role of Dermcidin isoform-2 in the occurrence and severity of Diabetes10.1038/s41598-017-07958-32045-2322https://doaj.org/article/814f1ff27d0041a081a5ec80c2e360772017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07958-3https://doaj.org/toc/2045-2322Abstract Diabetes is now epidemic worldwide. Several hundred-million peoples are presently suffering from this disease with other secondary-disorders. Stress, hypertension, sedentary life-style, carbohydrate/lipid metabolic-disorders due to genetic or environmental factors attributes to type-1 and/or type-2 diabetes. Present investigation demonstrates that stress-induced protein dermcidin isoform-2 (DCN-2) which appears in the serum of diabetic-patients play a key-role in this disease pathogenesis/severity. DCN-2 suppresses insulin production-release from liver/pancreas. It also increases the insulin-resistance. Stress-induction at the onset/progression of this disease is noticed as the high-level of lipid peroxides/low-level of free-thiols in association with increase of inflammatory-markers c-reactive protein and TNF-α. DCN-2 induced decrease in the synthesis of glucose-activated nitric oxide synthase (GANOS) and lower production of NO in liver has been shown here where NO is demonstrated to lower the expression of glucose trabsporter-4 (GLUT-4) and its translocation on liver membrane surface. This finally impairs glucose transport to organs from the extracellular fluid. Low level of glucose uptake further decreases glucose-induced insulin synthesis. The central role of DCN-2 has been demonstrated in type-1/type-2 diabetic individuals, in rodent hepatocytes and pancreatic-cell, tissue-slices, in-vitro and in-vivo experimental model. It can be concluded that stress-induced decrease in insulin synthesis/function, glucose transport is an interactive consequence of oxidative threats and inflammatory events.Suman BhattacharyaMd. Mobidullah KhanChandradipa GhoshSarbashri BankSmarajit MaitiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Suman Bhattacharya Md. Mobidullah Khan Chandradipa Ghosh Sarbashri Bank Smarajit Maiti The role of Dermcidin isoform-2 in the occurrence and severity of Diabetes
description	Abstract Diabetes is now epidemic worldwide. Several hundred-million peoples are presently suffering from this disease with other secondary-disorders. Stress, hypertension, sedentary life-style, carbohydrate/lipid metabolic-disorders due to genetic or environmental factors attributes to type-1 and/or type-2 diabetes. Present investigation demonstrates that stress-induced protein dermcidin isoform-2 (DCN-2) which appears in the serum of diabetic-patients play a key-role in this disease pathogenesis/severity. DCN-2 suppresses insulin production-release from liver/pancreas. It also increases the insulin-resistance. Stress-induction at the onset/progression of this disease is noticed as the high-level of lipid peroxides/low-level of free-thiols in association with increase of inflammatory-markers c-reactive protein and TNF-α. DCN-2 induced decrease in the synthesis of glucose-activated nitric oxide synthase (GANOS) and lower production of NO in liver has been shown here where NO is demonstrated to lower the expression of glucose trabsporter-4 (GLUT-4) and its translocation on liver membrane surface. This finally impairs glucose transport to organs from the extracellular fluid. Low level of glucose uptake further decreases glucose-induced insulin synthesis. The central role of DCN-2 has been demonstrated in type-1/type-2 diabetic individuals, in rodent hepatocytes and pancreatic-cell, tissue-slices, in-vitro and in-vivo experimental model. It can be concluded that stress-induced decrease in insulin synthesis/function, glucose transport is an interactive consequence of oxidative threats and inflammatory events.
format	article
author	Suman Bhattacharya Md. Mobidullah Khan Chandradipa Ghosh Sarbashri Bank Smarajit Maiti
author_facet	Suman Bhattacharya Md. Mobidullah Khan Chandradipa Ghosh Sarbashri Bank Smarajit Maiti
author_sort	Suman Bhattacharya
title	The role of Dermcidin isoform-2 in the occurrence and severity of Diabetes
title_short	The role of Dermcidin isoform-2 in the occurrence and severity of Diabetes
title_full	The role of Dermcidin isoform-2 in the occurrence and severity of Diabetes
title_fullStr	The role of Dermcidin isoform-2 in the occurrence and severity of Diabetes
title_full_unstemmed	The role of Dermcidin isoform-2 in the occurrence and severity of Diabetes
title_sort	role of dermcidin isoform-2 in the occurrence and severity of diabetes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/814f1ff27d0041a081a5ec80c2e36077
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The role of Dermcidin isoform-2 in the occurrence and severity of Diabetes

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