Prevalence and risk factors associated with Entamoeba histolytica/dispar/moshkovskii infection among three Orang Asli ethnic groups in Malaysia.

<h4>Background</h4>Entamoeba histolytica/Entamoeba dispar/Entamoeba moshkovskii infection is still prevalent in rural Malaysia especially among Orang Asli communities. Currently, information on prevalence of this infection among different ethnic groups of Orang Asli is unavailable in Mal...

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Autores principales:	Tengku Shahrul Anuar, Hesham M Al-Mekhlafi, Mohamed Kamel Abdul Ghani, Emelia Osman, Azlin Mohd Yasin, Anisah Nordin, Siti Nor Azreen, Fatmah Md Salleh, Nuraffini Ghazali, Mekadina Bernadus, Norhayati Moktar
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/814f83d883784d63a5f574321edb912f
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spelling	oai:doaj.org-article:814f83d883784d63a5f574321edb912f2021-11-18T08:10:58ZPrevalence and risk factors associated with Entamoeba histolytica/dispar/moshkovskii infection among three Orang Asli ethnic groups in Malaysia.1932-620310.1371/journal.pone.0048165https://doaj.org/article/814f83d883784d63a5f574321edb912f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23133561/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Entamoeba histolytica/Entamoeba dispar/Entamoeba moshkovskii infection is still prevalent in rural Malaysia especially among Orang Asli communities. Currently, information on prevalence of this infection among different ethnic groups of Orang Asli is unavailable in Malaysia. To contribute to a better comprehension of the epidemiology of this infection, a cross-sectional study aimed at providing the first documented data on the prevalence and risk factors associated with E. histolytica/E. dispar/E. moshkovskii infection was carried out among three Orang Asli ethnic groups (Proto-Malay, Negrito, and Senoi) in selected villages in Negeri Sembilan, Perak, and Pahang states, Malaysia.<h4>Methods/findings</h4>Faecal samples were examined by formalin-ether sedimentation and trichrome staining techniques. Of 500 individuals, 8.7% (13/150) of Proto-Malay, 29.5% (41/139) of Negrito, and 18.5% (39/211) of Senoi were positive for E. histolytica/E. dispar/E. moshkovskii, respectively. The prevalence of this infection showed an age-dependency relationship, with higher rates observed among those aged less than 15 years in all ethnic groups studied. Multivariate analysis confirmed that not washing hands after playing with soils or gardening and presence of other family members infected with E. histolytica/E. dispar/E. moshkovskii were significant risk factors of infection among all ethnic groups. However, eating with hands, the consumption of raw vegetables, and close contact with domestic animals were identified as significant risk factors in Senoi.<h4>Conclusions</h4>Essentially, the findings highlighted that E. histolytica/E. dispar/E. moshkovskii parasites are still prevalent in Malaysia. Further studies using molecular approaches to distinguish the morphologically identical species of pathogenic, E. histolytica from the non-pathogenic, E. dispar and E. moshkovskii are needed. The establishment of such data will be beneficial for the public health authorities in the planning and implementation of specific prevention and control strategies of this infection in different Orang Asli ethnic groups in Malaysia.Tengku Shahrul AnuarHesham M Al-MekhlafiMohamed Kamel Abdul GhaniEmelia OsmanAzlin Mohd YasinAnisah NordinSiti Nor AzreenFatmah Md SallehNuraffini GhazaliMekadina BernadusNorhayati MoktarPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e48165 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tengku Shahrul Anuar Hesham M Al-Mekhlafi Mohamed Kamel Abdul Ghani Emelia Osman Azlin Mohd Yasin Anisah Nordin Siti Nor Azreen Fatmah Md Salleh Nuraffini Ghazali Mekadina Bernadus Norhayati Moktar Prevalence and risk factors associated with Entamoeba histolytica/dispar/moshkovskii infection among three Orang Asli ethnic groups in Malaysia.
description	<h4>Background</h4>Entamoeba histolytica/Entamoeba dispar/Entamoeba moshkovskii infection is still prevalent in rural Malaysia especially among Orang Asli communities. Currently, information on prevalence of this infection among different ethnic groups of Orang Asli is unavailable in Malaysia. To contribute to a better comprehension of the epidemiology of this infection, a cross-sectional study aimed at providing the first documented data on the prevalence and risk factors associated with E. histolytica/E. dispar/E. moshkovskii infection was carried out among three Orang Asli ethnic groups (Proto-Malay, Negrito, and Senoi) in selected villages in Negeri Sembilan, Perak, and Pahang states, Malaysia.<h4>Methods/findings</h4>Faecal samples were examined by formalin-ether sedimentation and trichrome staining techniques. Of 500 individuals, 8.7% (13/150) of Proto-Malay, 29.5% (41/139) of Negrito, and 18.5% (39/211) of Senoi were positive for E. histolytica/E. dispar/E. moshkovskii, respectively. The prevalence of this infection showed an age-dependency relationship, with higher rates observed among those aged less than 15 years in all ethnic groups studied. Multivariate analysis confirmed that not washing hands after playing with soils or gardening and presence of other family members infected with E. histolytica/E. dispar/E. moshkovskii were significant risk factors of infection among all ethnic groups. However, eating with hands, the consumption of raw vegetables, and close contact with domestic animals were identified as significant risk factors in Senoi.<h4>Conclusions</h4>Essentially, the findings highlighted that E. histolytica/E. dispar/E. moshkovskii parasites are still prevalent in Malaysia. Further studies using molecular approaches to distinguish the morphologically identical species of pathogenic, E. histolytica from the non-pathogenic, E. dispar and E. moshkovskii are needed. The establishment of such data will be beneficial for the public health authorities in the planning and implementation of specific prevention and control strategies of this infection in different Orang Asli ethnic groups in Malaysia.
format	article
author	Tengku Shahrul Anuar Hesham M Al-Mekhlafi Mohamed Kamel Abdul Ghani Emelia Osman Azlin Mohd Yasin Anisah Nordin Siti Nor Azreen Fatmah Md Salleh Nuraffini Ghazali Mekadina Bernadus Norhayati Moktar
author_facet	Tengku Shahrul Anuar Hesham M Al-Mekhlafi Mohamed Kamel Abdul Ghani Emelia Osman Azlin Mohd Yasin Anisah Nordin Siti Nor Azreen Fatmah Md Salleh Nuraffini Ghazali Mekadina Bernadus Norhayati Moktar
author_sort	Tengku Shahrul Anuar
title	Prevalence and risk factors associated with Entamoeba histolytica/dispar/moshkovskii infection among three Orang Asli ethnic groups in Malaysia.
title_short	Prevalence and risk factors associated with Entamoeba histolytica/dispar/moshkovskii infection among three Orang Asli ethnic groups in Malaysia.
title_full	Prevalence and risk factors associated with Entamoeba histolytica/dispar/moshkovskii infection among three Orang Asli ethnic groups in Malaysia.
title_fullStr	Prevalence and risk factors associated with Entamoeba histolytica/dispar/moshkovskii infection among three Orang Asli ethnic groups in Malaysia.
title_full_unstemmed	Prevalence and risk factors associated with Entamoeba histolytica/dispar/moshkovskii infection among three Orang Asli ethnic groups in Malaysia.
title_sort	prevalence and risk factors associated with entamoeba histolytica/dispar/moshkovskii infection among three orang asli ethnic groups in malaysia.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/814f83d883784d63a5f574321edb912f
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Prevalence and risk factors associated with Entamoeba histolytica/dispar/moshkovskii infection among three Orang Asli ethnic groups in Malaysia.

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