Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus

Abstract Pharmaceuticals and personal care products (PPCPs) have been found in wastewater treatment plant (WWTP) effluents and their recipient watersheds. To assess the potential of WWTP effluents to alter fish behaviour, we caged male goldfish (Carassius auratus) for 21-days at three sites along a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	D. B. D. Simmons, E. S. McCallum, S. Balshine, B. Chandramouli, J. Cosgrove, J. P. Sherry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/81594d76827544428b08fa46a711e922
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:81594d76827544428b08fa46a711e922
record_format	dspace
spelling	oai:doaj.org-article:81594d76827544428b08fa46a711e9222021-12-02T15:06:11ZReduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus10.1038/s41598-017-15989-z2045-2322https://doaj.org/article/81594d76827544428b08fa46a711e9222017-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-15989-zhttps://doaj.org/toc/2045-2322Abstract Pharmaceuticals and personal care products (PPCPs) have been found in wastewater treatment plant (WWTP) effluents and their recipient watersheds. To assess the potential of WWTP effluents to alter fish behaviour, we caged male goldfish (Carassius auratus) for 21-days at three sites along a contamination gradient downstream from a WWTP which discharges into Cootes Paradise Marsh, on the western tip of Lake Ontario. We also included a fourth caging site as an external reference site within Lake Ontario at the Jordan Harbour Conservation Area. We then measured concentrations of PPCPs and monoamine neurotransmitters in caged goldfish plasma, and conducted behavioural assays measuring activity, startle response, and feeding. We detected fifteen different PPCPs in goldfish plasma including six serotonin reuptake inhibitors (amitriptyline, citalopram, fluoxetine/norfluoxetine, sertraline, venlafaxine, and diphenhydramine). Plasma concentrations of serotonin were significantly greater in plasma of fish caged closer to the WWTP effluent outfall site. The fish caged near and downstream of the WWTP effluent were bolder, more exploratory, and more active overall than fish caged at the reference site. Taken together, our results suggest that fish downstream of WWTPs are accumulating PPCPs at levels sufficient to alter neurotransmitter concentrations and to also impair ecologically-relevant behaviours.D. B. D. SimmonsE. S. McCallumS. BalshineB. ChandramouliJ. CosgroveJ. P. SherryNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q D. B. D. Simmons E. S. McCallum S. Balshine B. Chandramouli J. Cosgrove J. P. Sherry Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus
description	Abstract Pharmaceuticals and personal care products (PPCPs) have been found in wastewater treatment plant (WWTP) effluents and their recipient watersheds. To assess the potential of WWTP effluents to alter fish behaviour, we caged male goldfish (Carassius auratus) for 21-days at three sites along a contamination gradient downstream from a WWTP which discharges into Cootes Paradise Marsh, on the western tip of Lake Ontario. We also included a fourth caging site as an external reference site within Lake Ontario at the Jordan Harbour Conservation Area. We then measured concentrations of PPCPs and monoamine neurotransmitters in caged goldfish plasma, and conducted behavioural assays measuring activity, startle response, and feeding. We detected fifteen different PPCPs in goldfish plasma including six serotonin reuptake inhibitors (amitriptyline, citalopram, fluoxetine/norfluoxetine, sertraline, venlafaxine, and diphenhydramine). Plasma concentrations of serotonin were significantly greater in plasma of fish caged closer to the WWTP effluent outfall site. The fish caged near and downstream of the WWTP effluent were bolder, more exploratory, and more active overall than fish caged at the reference site. Taken together, our results suggest that fish downstream of WWTPs are accumulating PPCPs at levels sufficient to alter neurotransmitter concentrations and to also impair ecologically-relevant behaviours.
format	article
author	D. B. D. Simmons E. S. McCallum S. Balshine B. Chandramouli J. Cosgrove J. P. Sherry
author_facet	D. B. D. Simmons E. S. McCallum S. Balshine B. Chandramouli J. Cosgrove J. P. Sherry
author_sort	D. B. D. Simmons
title	Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus
title_short	Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus
title_full	Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus
title_fullStr	Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus
title_full_unstemmed	Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus
title_sort	reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish carassius auratus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/81594d76827544428b08fa46a711e922
work_keys_str_mv	AT dbdsimmons reducedanxietyisassociatedwiththeaccumulationofsixserotoninreuptakeinhibitorsinwastewatertreatmenteffluentexposedgoldfishcarassiusauratus AT esmccallum reducedanxietyisassociatedwiththeaccumulationofsixserotoninreuptakeinhibitorsinwastewatertreatmenteffluentexposedgoldfishcarassiusauratus AT sbalshine reducedanxietyisassociatedwiththeaccumulationofsixserotoninreuptakeinhibitorsinwastewatertreatmenteffluentexposedgoldfishcarassiusauratus AT bchandramouli reducedanxietyisassociatedwiththeaccumulationofsixserotoninreuptakeinhibitorsinwastewatertreatmenteffluentexposedgoldfishcarassiusauratus AT jcosgrove reducedanxietyisassociatedwiththeaccumulationofsixserotoninreuptakeinhibitorsinwastewatertreatmenteffluentexposedgoldfishcarassiusauratus AT jpsherry reducedanxietyisassociatedwiththeaccumulationofsixserotoninreuptakeinhibitorsinwastewatertreatmenteffluentexposedgoldfishcarassiusauratus
_version_	1718388592466722816

Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus

Ejemplares similares