Monocular deprivation induces dendritic spine elimination in the developing mouse visual cortex

Abstract It is well established that visual deprivation has a profound impact on the responsiveness of neurons in the developing visual cortex. The effect of visual deprivation on synaptic connectivity remains unclear. Using transcranial two-photon microscopy, we examined the effect of visual depriv...

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Autores principales:	Yanmei Zhou, Baoling Lai, Wen-Biao Gan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/815a025b981643f3b26bd8731d90552f
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spelling	oai:doaj.org-article:815a025b981643f3b26bd8731d90552f2021-12-02T12:30:35ZMonocular deprivation induces dendritic spine elimination in the developing mouse visual cortex10.1038/s41598-017-05337-62045-2322https://doaj.org/article/815a025b981643f3b26bd8731d90552f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05337-6https://doaj.org/toc/2045-2322Abstract It is well established that visual deprivation has a profound impact on the responsiveness of neurons in the developing visual cortex. The effect of visual deprivation on synaptic connectivity remains unclear. Using transcranial two-photon microscopy, we examined the effect of visual deprivation and subsequent recovery on dendritic spine remodeling of layer 5 pyramidal neurons in the mouse primary visual cortex. We found that monocular deprivation (MD), but not binocular deprivation (BD), increased dendritic spine elimination over 3 days in the binocular region of 4-week-old adolescent mice. This MD-induced dendritic spine elimination persisted during subsequent 2–4 days of binocular recovery. Furthermore, we found that average dendritic spine sizes were decreased and increased following 3-day MD and BD, respectively. These spine size changes induced by MD or BD tended to be reversed during subsequent binocular recovery. Taken together, these findings reveal differential effects of MD and BD on synaptic connectivity of layer 5 pyramidal neurons and underscore the persistent impact of MD on synapse loss in the developing visual cortex.Yanmei ZhouBaoling LaiWen-Biao GanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yanmei Zhou Baoling Lai Wen-Biao Gan Monocular deprivation induces dendritic spine elimination in the developing mouse visual cortex
description	Abstract It is well established that visual deprivation has a profound impact on the responsiveness of neurons in the developing visual cortex. The effect of visual deprivation on synaptic connectivity remains unclear. Using transcranial two-photon microscopy, we examined the effect of visual deprivation and subsequent recovery on dendritic spine remodeling of layer 5 pyramidal neurons in the mouse primary visual cortex. We found that monocular deprivation (MD), but not binocular deprivation (BD), increased dendritic spine elimination over 3 days in the binocular region of 4-week-old adolescent mice. This MD-induced dendritic spine elimination persisted during subsequent 2–4 days of binocular recovery. Furthermore, we found that average dendritic spine sizes were decreased and increased following 3-day MD and BD, respectively. These spine size changes induced by MD or BD tended to be reversed during subsequent binocular recovery. Taken together, these findings reveal differential effects of MD and BD on synaptic connectivity of layer 5 pyramidal neurons and underscore the persistent impact of MD on synapse loss in the developing visual cortex.
format	article
author	Yanmei Zhou Baoling Lai Wen-Biao Gan
author_facet	Yanmei Zhou Baoling Lai Wen-Biao Gan
author_sort	Yanmei Zhou
title	Monocular deprivation induces dendritic spine elimination in the developing mouse visual cortex
title_short	Monocular deprivation induces dendritic spine elimination in the developing mouse visual cortex
title_full	Monocular deprivation induces dendritic spine elimination in the developing mouse visual cortex
title_fullStr	Monocular deprivation induces dendritic spine elimination in the developing mouse visual cortex
title_full_unstemmed	Monocular deprivation induces dendritic spine elimination in the developing mouse visual cortex
title_sort	monocular deprivation induces dendritic spine elimination in the developing mouse visual cortex
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/815a025b981643f3b26bd8731d90552f
work_keys_str_mv	AT yanmeizhou monoculardeprivationinducesdendriticspineeliminationinthedevelopingmousevisualcortex AT baolinglai monoculardeprivationinducesdendriticspineeliminationinthedevelopingmousevisualcortex AT wenbiaogan monoculardeprivationinducesdendriticspineeliminationinthedevelopingmousevisualcortex
_version_	1718394345431760896

Monocular deprivation induces dendritic spine elimination in the developing mouse visual cortex

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