Shifting Perspectives of Translational Research in Bio-Bactericides: Reviewing the <i>Bacillus amyloliquefaciens</i> Paradigm

Bacterial biological control agents (BCAs) have been increasingly used against plant diseases. The traditional approach to manufacturing such commercial products was based on the selection of bacterial species able to produce secondary metabolites that inhibit mainly fungal growth in optimal media....

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Autores principales:	Anastasia Dimopoulou, Ioannis Theologidis, Adamantia Varympopi, Dimitris Papafotis, Glykeria Mermigka, Aliki Tzima, Nick J. Panopoulos, Nicholas Skandalis
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biological control agents BCAs bacterial biological control environmental impact Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/815add5e7856487f944536e454e1c0bd
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spelling	oai:doaj.org-article:815add5e7856487f944536e454e1c0bd2021-11-25T16:47:57ZShifting Perspectives of Translational Research in Bio-Bactericides: Reviewing the <i>Bacillus amyloliquefaciens</i> Paradigm10.3390/biology101112022079-7737https://doaj.org/article/815add5e7856487f944536e454e1c0bd2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-7737/10/11/1202https://doaj.org/toc/2079-7737Bacterial biological control agents (BCAs) have been increasingly used against plant diseases. The traditional approach to manufacturing such commercial products was based on the selection of bacterial species able to produce secondary metabolites that inhibit mainly fungal growth in optimal media. Such species are required to be massively produced and sustain long-term self-storage. The endpoint of this pipeline is large-scale field tests in which BCAs are handled as any other pesticide. Despite recent knowledge of the importance of BCA-host-microbiome interactions to trigger plant defenses and allow colonization, holistic approaches to maximize their potential are still in their infancy. There is a gap in scientific knowledge between experiments in controlled conditions for optimal BCA and pathogen growth and the nutrient-limited field conditions in which they face niche microbiota competition. Moreover, BCAs are considered to be safe by competent authorities and the public, with no side effects to the environment; the OneHealth impact of their application is understudied. This review summarizes the state of the art in BCA research and how current knowledge and new biotechnological tools have impacted BCA development and application. Future challenges, such as their combinational use and ability to ameliorate plant stress are also discussed. Addressing such challenges would establish their long-term use as centerfold agricultural pesticides and plant growth promoters.Anastasia DimopoulouIoannis TheologidisAdamantia VarympopiDimitris PapafotisGlykeria MermigkaAliki TzimaNick J. PanopoulosNicholas SkandalisMDPI AGarticlebiological control agentsBCAsbacterial biological controlenvironmental impactBiology (General)QH301-705.5ENBiology, Vol 10, Iss 1202, p 1202 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biological control agents BCAs bacterial biological control environmental impact Biology (General) QH301-705.5
spellingShingle	biological control agents BCAs bacterial biological control environmental impact Biology (General) QH301-705.5 Anastasia Dimopoulou Ioannis Theologidis Adamantia Varympopi Dimitris Papafotis Glykeria Mermigka Aliki Tzima Nick J. Panopoulos Nicholas Skandalis Shifting Perspectives of Translational Research in Bio-Bactericides: Reviewing the <i>Bacillus amyloliquefaciens</i> Paradigm
description	Bacterial biological control agents (BCAs) have been increasingly used against plant diseases. The traditional approach to manufacturing such commercial products was based on the selection of bacterial species able to produce secondary metabolites that inhibit mainly fungal growth in optimal media. Such species are required to be massively produced and sustain long-term self-storage. The endpoint of this pipeline is large-scale field tests in which BCAs are handled as any other pesticide. Despite recent knowledge of the importance of BCA-host-microbiome interactions to trigger plant defenses and allow colonization, holistic approaches to maximize their potential are still in their infancy. There is a gap in scientific knowledge between experiments in controlled conditions for optimal BCA and pathogen growth and the nutrient-limited field conditions in which they face niche microbiota competition. Moreover, BCAs are considered to be safe by competent authorities and the public, with no side effects to the environment; the OneHealth impact of their application is understudied. This review summarizes the state of the art in BCA research and how current knowledge and new biotechnological tools have impacted BCA development and application. Future challenges, such as their combinational use and ability to ameliorate plant stress are also discussed. Addressing such challenges would establish their long-term use as centerfold agricultural pesticides and plant growth promoters.
format	article
author	Anastasia Dimopoulou Ioannis Theologidis Adamantia Varympopi Dimitris Papafotis Glykeria Mermigka Aliki Tzima Nick J. Panopoulos Nicholas Skandalis
author_facet	Anastasia Dimopoulou Ioannis Theologidis Adamantia Varympopi Dimitris Papafotis Glykeria Mermigka Aliki Tzima Nick J. Panopoulos Nicholas Skandalis
author_sort	Anastasia Dimopoulou
title	Shifting Perspectives of Translational Research in Bio-Bactericides: Reviewing the <i>Bacillus amyloliquefaciens</i> Paradigm
title_short	Shifting Perspectives of Translational Research in Bio-Bactericides: Reviewing the <i>Bacillus amyloliquefaciens</i> Paradigm
title_full	Shifting Perspectives of Translational Research in Bio-Bactericides: Reviewing the <i>Bacillus amyloliquefaciens</i> Paradigm
title_fullStr	Shifting Perspectives of Translational Research in Bio-Bactericides: Reviewing the <i>Bacillus amyloliquefaciens</i> Paradigm
title_full_unstemmed	Shifting Perspectives of Translational Research in Bio-Bactericides: Reviewing the <i>Bacillus amyloliquefaciens</i> Paradigm
title_sort	shifting perspectives of translational research in bio-bactericides: reviewing the <i>bacillus amyloliquefaciens</i> paradigm
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/815add5e7856487f944536e454e1c0bd
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Shifting Perspectives of Translational Research in Bio-Bactericides: Reviewing the <i>Bacillus amyloliquefaciens</i> Paradigm

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