The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model
Dysregulation of microRNAs has been implicated in neurodevelopmental disorders, including schizophrenia. Here the authors show that the TLX-miR-219 cascade regulates the proliferation of neural stem cells during normal development, and this pathway is dysregulated in a schizophrenia iPSC model.
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Nature Portfolio
2016
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oai:doaj.org-article:815b09098f9142609850b28f3396fa6f2021-12-02T17:32:50ZThe TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model10.1038/ncomms109652041-1723https://doaj.org/article/815b09098f9142609850b28f3396fa6f2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10965https://doaj.org/toc/2041-1723Dysregulation of microRNAs has been implicated in neurodevelopmental disorders, including schizophrenia. Here the authors show that the TLX-miR-219 cascade regulates the proliferation of neural stem cells during normal development, and this pathway is dysregulated in a schizophrenia iPSC model.Kiyohito MuraiGuoqiang SunPeng YeE. TianSu YangQi CuiGuihua SunDaniel TrinhOlivia SunTeresa HongZhexing WenMarkus KalkumArthur D. RiggsHongjun SongGuo-li MingYanhong ShiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016) |
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DOAJ |
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EN |
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Science Q |
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Science Q Kiyohito Murai Guoqiang Sun Peng Ye E. Tian Su Yang Qi Cui Guihua Sun Daniel Trinh Olivia Sun Teresa Hong Zhexing Wen Markus Kalkum Arthur D. Riggs Hongjun Song Guo-li Ming Yanhong Shi The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model |
| description |
Dysregulation of microRNAs has been implicated in neurodevelopmental disorders, including schizophrenia. Here the authors show that the TLX-miR-219 cascade regulates the proliferation of neural stem cells during normal development, and this pathway is dysregulated in a schizophrenia iPSC model. |
| format |
article |
| author |
Kiyohito Murai Guoqiang Sun Peng Ye E. Tian Su Yang Qi Cui Guihua Sun Daniel Trinh Olivia Sun Teresa Hong Zhexing Wen Markus Kalkum Arthur D. Riggs Hongjun Song Guo-li Ming Yanhong Shi |
| author_facet |
Kiyohito Murai Guoqiang Sun Peng Ye E. Tian Su Yang Qi Cui Guihua Sun Daniel Trinh Olivia Sun Teresa Hong Zhexing Wen Markus Kalkum Arthur D. Riggs Hongjun Song Guo-li Ming Yanhong Shi |
| author_sort |
Kiyohito Murai |
| title |
The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model |
| title_short |
The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model |
| title_full |
The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model |
| title_fullStr |
The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model |
| title_full_unstemmed |
The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model |
| title_sort |
tlx-mir-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia ipsc model |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/815b09098f9142609850b28f3396fa6f |
| work_keys_str_mv |
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