The comparative immunology of wild and laboratory mice, Mus musculus domesticus

Laboratory mice are the cornerstone of immunology but how well they represent wild mice is not clear. Here the authors compare and contrast various immune parameters between wild-caught mice and laboratory (C57BL/6) mice and identify a previously unknown myeloid cell population specific to wild mice...

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Main Authors: Stephen Abolins, Elizabeth C. King, Luke Lazarou, Laura Weldon, Louise Hughes, Paul Drescher, John G. Raynes, Julius C. R. Hafalla, Mark E. Viney, Eleanor M. Riley
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/815dfef893d7436cb44e02528fe4cbfc
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Summary:Laboratory mice are the cornerstone of immunology but how well they represent wild mice is not clear. Here the authors compare and contrast various immune parameters between wild-caught mice and laboratory (C57BL/6) mice and identify a previously unknown myeloid cell population specific to wild mice.