The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis

The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis

REGγ is a component of ubiquitin-independent 20S proteasome that targets many regulatory proteins for degradation. Here the authors show that REGγ is induced in DSS colitis and promotes degradation of IκBɛ, and that REGγ-deficient mice have less NFκB activation and are more resistant to the disease....

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Autores principales: Jinjin Xu, Lei Zhou, Lei Ji, Fengyuan Chen, Karen Fortmann, Kun Zhang, Qingwu Liu, Ke Li, Weicang Wang, Hao Wang, Wei Xie, Qingwei Wang, Jiang Liu, Biao Zheng, Pei Zhang, Shixia Huang, Tieliu Shi, Biaohong Zhang, Yongyan Dang, Jiwu Chen, Bert W. O’Malley, Robb E. Moses, Ping Wang, Lei Li, Jianru Xiao, Alexander Hoffmann, Xiaotao Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/815ed3c7811843c397e9095adc1ff9cf
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Sumario:REGγ is a component of ubiquitin-independent 20S proteasome that targets many regulatory proteins for degradation. Here the authors show that REGγ is induced in DSS colitis and promotes degradation of IκBɛ, and that REGγ-deficient mice have less NFκB activation and are more resistant to the disease.

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