The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis
REGγ is a component of ubiquitin-independent 20S proteasome that targets many regulatory proteins for degradation. Here the authors show that REGγ is induced in DSS colitis and promotes degradation of IκBɛ, and that REGγ-deficient mice have less NFκB activation and are more resistant to the disease....
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Nature Portfolio
2016
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oai:doaj.org-article:815ed3c7811843c397e9095adc1ff9cf2021-12-02T17:32:39ZThe REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis10.1038/ncomms107612041-1723https://doaj.org/article/815ed3c7811843c397e9095adc1ff9cf2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10761https://doaj.org/toc/2041-1723REGγ is a component of ubiquitin-independent 20S proteasome that targets many regulatory proteins for degradation. Here the authors show that REGγ is induced in DSS colitis and promotes degradation of IκBɛ, and that REGγ-deficient mice have less NFκB activation and are more resistant to the disease.Jinjin XuLei ZhouLei JiFengyuan ChenKaren FortmannKun ZhangQingwu LiuKe LiWeicang WangHao WangWei XieQingwei WangJiang LiuBiao ZhengPei ZhangShixia HuangTieliu ShiBiaohong ZhangYongyan DangJiwu ChenBert W. O’MalleyRobb E. MosesPing WangLei LiJianru XiaoAlexander HoffmannXiaotao LiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jinjin Xu Lei Zhou Lei Ji Fengyuan Chen Karen Fortmann Kun Zhang Qingwu Liu Ke Li Weicang Wang Hao Wang Wei Xie Qingwei Wang Jiang Liu Biao Zheng Pei Zhang Shixia Huang Tieliu Shi Biaohong Zhang Yongyan Dang Jiwu Chen Bert W. O’Malley Robb E. Moses Ping Wang Lei Li Jianru Xiao Alexander Hoffmann Xiaotao Li The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis |
| description |
REGγ is a component of ubiquitin-independent 20S proteasome that targets many regulatory proteins for degradation. Here the authors show that REGγ is induced in DSS colitis and promotes degradation of IκBɛ, and that REGγ-deficient mice have less NFκB activation and are more resistant to the disease. |
| format |
article |
| author |
Jinjin Xu Lei Zhou Lei Ji Fengyuan Chen Karen Fortmann Kun Zhang Qingwu Liu Ke Li Weicang Wang Hao Wang Wei Xie Qingwei Wang Jiang Liu Biao Zheng Pei Zhang Shixia Huang Tieliu Shi Biaohong Zhang Yongyan Dang Jiwu Chen Bert W. O’Malley Robb E. Moses Ping Wang Lei Li Jianru Xiao Alexander Hoffmann Xiaotao Li |
| author_facet |
Jinjin Xu Lei Zhou Lei Ji Fengyuan Chen Karen Fortmann Kun Zhang Qingwu Liu Ke Li Weicang Wang Hao Wang Wei Xie Qingwei Wang Jiang Liu Biao Zheng Pei Zhang Shixia Huang Tieliu Shi Biaohong Zhang Yongyan Dang Jiwu Chen Bert W. O’Malley Robb E. Moses Ping Wang Lei Li Jianru Xiao Alexander Hoffmann Xiaotao Li |
| author_sort |
Jinjin Xu |
| title |
The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis |
| title_short |
The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis |
| title_full |
The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis |
| title_fullStr |
The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis |
| title_full_unstemmed |
The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis |
| title_sort |
regγ-proteasome forms a regulatory circuit with iκbɛ and nfκb in experimental colitis |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/815ed3c7811843c397e9095adc1ff9cf |
| work_keys_str_mv |
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