The tumor immune microenvironment of primary and metastatic HER2− positive breast cancers utilizing gene expression and spatial proteomic profiling

The tumor immune microenvironment of primary and metastatic HER2− positive breast cancers utilizing gene expression and spatial proteomic profiling

Abstract Background The characterization of the immune component of the tumor microenvironment (TME) of human epidermal growth factor receptor 2 positive (HER2+) breast cancer has been limited. Molecular and spatial characterization of HER2+ TME of primary, recurrent, and metastatic breast tumors ha...

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Bibliographic Details
Main Authors: Ilana Schlam, Sarah E. Church, Tyler D. Hether, Krysta Chaldekas, Briana M. Hudson, Andrew M. White, Emily Maisonet, Brent T. Harris, Sandra M. Swain
Format: article
Language:EN
Published: BMC 2021
Subjects:
Breast cancer
HER2 positive
Tumor microenvironment
Digital spatial profiling
Gene expression profiling
Medicine
R
Online Access:https://doaj.org/article/815f26c1bb0147c2a0736d6023a43c34
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