TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro

Mutations in CHCHD10 can cause amyotrophic lateral sclerosis and frontotemporal dementia. The authors generate mutant Drosophila and HeLa cells to study the underlying mechanisms of CHCHD10S59L -induced degeneration and show it is mediated by TDP-43 and PINK1 pathways.

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Autores principales:	Minwoo Baek, Yun-Jeong Choe, Sylvie Bannwarth, JiHye Kim, Swati Maitra, Gerald W. Dorn, J. Paul Taylor, Veronique Paquis-Flucklinger, Nam Chul Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8160d8738a574843b32491ceca43935e
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spelling	oai:doaj.org-article:8160d8738a574843b32491ceca43935e2021-12-02T17:04:01ZTDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro10.1038/s41467-021-22145-92041-1723https://doaj.org/article/8160d8738a574843b32491ceca43935e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22145-9https://doaj.org/toc/2041-1723Mutations in CHCHD10 can cause amyotrophic lateral sclerosis and frontotemporal dementia. The authors generate mutant Drosophila and HeLa cells to study the underlying mechanisms of CHCHD10S59L -induced degeneration and show it is mediated by TDP-43 and PINK1 pathways.Minwoo BaekYun-Jeong ChoeSylvie BannwarthJiHye KimSwati MaitraGerald W. DornJ. Paul TaylorVeronique Paquis-FlucklingerNam Chul KimNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Minwoo Baek Yun-Jeong Choe Sylvie Bannwarth JiHye Kim Swati Maitra Gerald W. Dorn J. Paul Taylor Veronique Paquis-Flucklinger Nam Chul Kim TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro
description	Mutations in CHCHD10 can cause amyotrophic lateral sclerosis and frontotemporal dementia. The authors generate mutant Drosophila and HeLa cells to study the underlying mechanisms of CHCHD10S59L -induced degeneration and show it is mediated by TDP-43 and PINK1 pathways.
format	article
author	Minwoo Baek Yun-Jeong Choe Sylvie Bannwarth JiHye Kim Swati Maitra Gerald W. Dorn J. Paul Taylor Veronique Paquis-Flucklinger Nam Chul Kim
author_facet	Minwoo Baek Yun-Jeong Choe Sylvie Bannwarth JiHye Kim Swati Maitra Gerald W. Dorn J. Paul Taylor Veronique Paquis-Flucklinger Nam Chul Kim
author_sort	Minwoo Baek
title	TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro
title_short	TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro
title_full	TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro
title_fullStr	TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro
title_full_unstemmed	TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro
title_sort	tdp-43 and pink1 mediate chchd10 s59l mutation–induced defects in drosophila and in vitro
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8160d8738a574843b32491ceca43935e
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TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro

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