ASSESSMENT OF BIOLOGICAL PROPERTIES OF CONCENTRATE OF NANOSTRUCTURES BASED ON SILICON DIOXIDE

Safety assessment of new nanostructured treatments and substances requires special attention from producers during synthesis and technological cycle and from the medical staff examining the persons contacting them. Toxicity studies should be conducted before the beginning of their use, in order not...

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Autores principales:	L. M. Sosedova, V. A. Vokina, V. V. Kondratiev, E. V. Yermolovich, A. A. Berezin
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	silicon dioxide nanostructures laboratory animals toxicity Science Q
Acceso en línea:	https://doaj.org/article/8164d3a5943944e1a5078796927e2769
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spelling	oai:doaj.org-article:8164d3a5943944e1a5078796927e27692021-11-23T06:14:38ZASSESSMENT OF BIOLOGICAL PROPERTIES OF CONCENTRATE OF NANOSTRUCTURES BASED ON SILICON DIOXIDE2541-94202587-959610.12737/article_59fad51eabec42.36876089https://doaj.org/article/8164d3a5943944e1a5078796927e27692017-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/421https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Safety assessment of new nanostructured treatments and substances requires special attention from producers during synthesis and technological cycle and from the medical staff examining the persons contacting them. Toxicity studies should be conducted before the beginning of their use, in order not to allow producing of nanopreparations with detrimental effects on human health. In the current economic climate, use of wastes from the production of metal silicon is promising. The article deals with the safety problems resulting from contact with wastes from the production of metal silicon. Concentrate of nanostructures based on silicon dioxide contained separate 1 μm nanoparticles and agglomerates from 1 to 45 ßm has been investigated. This concentrate is a perspective additive to increase sustainability properties of building materials. The objective of the research was to examine biological properties of siliceous dust administered to rats through various routes. Acute toxicity, species and sexual sensitivity after oral administration of the concentrate of nanostructures in mice and rats of both sexes, acute skin irritation from a single exposure were studied. The concentrate of nanostructures based on silicon dioxide can be classified in V category of hazard based on acute oral toxicity by classic toxicological methods (DL50 > 2000 mg/kg, no sexual and specific sensitivity). It produces slight irritating effect in acute dermal toxicity test that will disappear completely within 16 hours of exposure.L. M. SosedovaV. A. VokinaV. V. KondratievE. V. YermolovichA. A. BerezinScientific Сentre for Family Health and Human Reproduction Problemsarticlesilicon dioxidenanostructureslaboratory animalstoxicityScienceQRUActa Biomedica Scientifica, Vol 2, Iss 4, Pp 97-100 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	silicon dioxide nanostructures laboratory animals toxicity Science Q
spellingShingle	silicon dioxide nanostructures laboratory animals toxicity Science Q L. M. Sosedova V. A. Vokina V. V. Kondratiev E. V. Yermolovich A. A. Berezin ASSESSMENT OF BIOLOGICAL PROPERTIES OF CONCENTRATE OF NANOSTRUCTURES BASED ON SILICON DIOXIDE
description	Safety assessment of new nanostructured treatments and substances requires special attention from producers during synthesis and technological cycle and from the medical staff examining the persons contacting them. Toxicity studies should be conducted before the beginning of their use, in order not to allow producing of nanopreparations with detrimental effects on human health. In the current economic climate, use of wastes from the production of metal silicon is promising. The article deals with the safety problems resulting from contact with wastes from the production of metal silicon. Concentrate of nanostructures based on silicon dioxide contained separate 1 μm nanoparticles and agglomerates from 1 to 45 ßm has been investigated. This concentrate is a perspective additive to increase sustainability properties of building materials. The objective of the research was to examine biological properties of siliceous dust administered to rats through various routes. Acute toxicity, species and sexual sensitivity after oral administration of the concentrate of nanostructures in mice and rats of both sexes, acute skin irritation from a single exposure were studied. The concentrate of nanostructures based on silicon dioxide can be classified in V category of hazard based on acute oral toxicity by classic toxicological methods (DL50 > 2000 mg/kg, no sexual and specific sensitivity). It produces slight irritating effect in acute dermal toxicity test that will disappear completely within 16 hours of exposure.
format	article
author	L. M. Sosedova V. A. Vokina V. V. Kondratiev E. V. Yermolovich A. A. Berezin
author_facet	L. M. Sosedova V. A. Vokina V. V. Kondratiev E. V. Yermolovich A. A. Berezin
author_sort	L. M. Sosedova
title	ASSESSMENT OF BIOLOGICAL PROPERTIES OF CONCENTRATE OF NANOSTRUCTURES BASED ON SILICON DIOXIDE
title_short	ASSESSMENT OF BIOLOGICAL PROPERTIES OF CONCENTRATE OF NANOSTRUCTURES BASED ON SILICON DIOXIDE
title_full	ASSESSMENT OF BIOLOGICAL PROPERTIES OF CONCENTRATE OF NANOSTRUCTURES BASED ON SILICON DIOXIDE
title_fullStr	ASSESSMENT OF BIOLOGICAL PROPERTIES OF CONCENTRATE OF NANOSTRUCTURES BASED ON SILICON DIOXIDE
title_full_unstemmed	ASSESSMENT OF BIOLOGICAL PROPERTIES OF CONCENTRATE OF NANOSTRUCTURES BASED ON SILICON DIOXIDE
title_sort	assessment of biological properties of concentrate of nanostructures based on silicon dioxide
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/8164d3a5943944e1a5078796927e2769
work_keys_str_mv	AT lmsosedova assessmentofbiologicalpropertiesofconcentrateofnanostructuresbasedonsilicondioxide AT vavokina assessmentofbiologicalpropertiesofconcentrateofnanostructuresbasedonsilicondioxide AT vvkondratiev assessmentofbiologicalpropertiesofconcentrateofnanostructuresbasedonsilicondioxide AT evyermolovich assessmentofbiologicalpropertiesofconcentrateofnanostructuresbasedonsilicondioxide AT aaberezin assessmentofbiologicalpropertiesofconcentrateofnanostructuresbasedonsilicondioxide
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ASSESSMENT OF BIOLOGICAL PROPERTIES OF CONCENTRATE OF NANOSTRUCTURES BASED ON SILICON DIOXIDE

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