Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

The mechanisms underlying Huntingtin protein (Htt) aggregation are not fully understood. Here the authors perform a detailed investigation of the ultrastructural and biochemical properties of huntingtin cytoplasmic and nuclear inclusions, and reveal that they form via distinct mechanisms and exert t...

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Autores principales:	Nathan Riguet, Anne-Laure Mahul-Mellier, Niran Maharjan, Johannes Burtscher, Marie Croisier, Graham Knott, Janna Hastings, Alice Patin, Veronika Reiterer, Hesso Farhan, Sergey Nasarov, Hilal A. Lashuel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81663cd6def2472ea737c63e01d4fdd8
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spelling	oai:doaj.org-article:81663cd6def2472ea737c63e01d4fdd82021-11-14T12:35:48ZNuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties10.1038/s41467-021-26684-z2041-1723https://doaj.org/article/81663cd6def2472ea737c63e01d4fdd82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26684-zhttps://doaj.org/toc/2041-1723The mechanisms underlying Huntingtin protein (Htt) aggregation are not fully understood. Here the authors perform a detailed investigation of the ultrastructural and biochemical properties of huntingtin cytoplasmic and nuclear inclusions, and reveal that they form via distinct mechanisms and exert their toxicity via different pathways.Nathan RiguetAnne-Laure Mahul-MellierNiran MaharjanJohannes BurtscherMarie CroisierGraham KnottJanna HastingsAlice PatinVeronika ReitererHesso FarhanSergey NasarovHilal A. LashuelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-27 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nathan Riguet Anne-Laure Mahul-Mellier Niran Maharjan Johannes Burtscher Marie Croisier Graham Knott Janna Hastings Alice Patin Veronika Reiterer Hesso Farhan Sergey Nasarov Hilal A. Lashuel Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
description	The mechanisms underlying Huntingtin protein (Htt) aggregation are not fully understood. Here the authors perform a detailed investigation of the ultrastructural and biochemical properties of huntingtin cytoplasmic and nuclear inclusions, and reveal that they form via distinct mechanisms and exert their toxicity via different pathways.
format	article
author	Nathan Riguet Anne-Laure Mahul-Mellier Niran Maharjan Johannes Burtscher Marie Croisier Graham Knott Janna Hastings Alice Patin Veronika Reiterer Hesso Farhan Sergey Nasarov Hilal A. Lashuel
author_facet	Nathan Riguet Anne-Laure Mahul-Mellier Niran Maharjan Johannes Burtscher Marie Croisier Graham Knott Janna Hastings Alice Patin Veronika Reiterer Hesso Farhan Sergey Nasarov Hilal A. Lashuel
author_sort	Nathan Riguet
title	Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
title_short	Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
title_full	Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
title_fullStr	Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
title_full_unstemmed	Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
title_sort	nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/81663cd6def2472ea737c63e01d4fdd8
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Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

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