Intestinal anti-inflammatory activity of Ulva ohnoi oil in DSS-induced experimental mouse model

Abstract This study was conducted to examine the physiological activity of Ulva ohnoi, some of which may be used for food or natural products but could disturbing coastal ecosystems due to large scale green-tide, to check values of U. ohnoi oil through experimental results. U. ohnoi oil was extracte...

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Autores principales:	JeongEun Kang, JiSun Park, Jung-Kil Seo, WonHyung Choi, SooCheol Choi, Ju-Hyoung Kim, In-Ah Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/816a5f988966469093a0b730449ffe0e
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spelling	oai:doaj.org-article:816a5f988966469093a0b730449ffe0e2021-12-02T17:55:13ZIntestinal anti-inflammatory activity of Ulva ohnoi oil in DSS-induced experimental mouse model10.1038/s41598-021-94475-z2045-2322https://doaj.org/article/816a5f988966469093a0b730449ffe0e2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94475-zhttps://doaj.org/toc/2045-2322Abstract This study was conducted to examine the physiological activity of Ulva ohnoi, some of which may be used for food or natural products but could disturbing coastal ecosystems due to large scale green-tide, to check values of U. ohnoi oil through experimental results. U. ohnoi oil was extracted from bulk of Ulva biomass to confirm its antioxidant and antibacterial activity, and the efficacy of U. ohnoi oil in the state of inflammation was confirmed through animal experiments. To confirm the anti-inflammatory effect, a mouse model induced with DSS was used. As a result of measuring NO using plasma after induction of inflammation, the amount of NO produced in the U. ohnoi oil group was decreased compared to the control group. Expression of inflammatory cytokines TNF-α, IL-6, and IL-1β was decreased compared to the control group. As a result of observing H&E staining, lower crypt loss and inflammatory cell infiltration were found in the U. ohnoi oil group compared to the control group. Consequently, U. ohnoi oil appears to have great anti-inflammatory properties.JeongEun KangJiSun ParkJung-Kil SeoWonHyung ChoiSooCheol ChoiJu-Hyoung KimIn-Ah LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q JeongEun Kang JiSun Park Jung-Kil Seo WonHyung Choi SooCheol Choi Ju-Hyoung Kim In-Ah Lee Intestinal anti-inflammatory activity of Ulva ohnoi oil in DSS-induced experimental mouse model
description	Abstract This study was conducted to examine the physiological activity of Ulva ohnoi, some of which may be used for food or natural products but could disturbing coastal ecosystems due to large scale green-tide, to check values of U. ohnoi oil through experimental results. U. ohnoi oil was extracted from bulk of Ulva biomass to confirm its antioxidant and antibacterial activity, and the efficacy of U. ohnoi oil in the state of inflammation was confirmed through animal experiments. To confirm the anti-inflammatory effect, a mouse model induced with DSS was used. As a result of measuring NO using plasma after induction of inflammation, the amount of NO produced in the U. ohnoi oil group was decreased compared to the control group. Expression of inflammatory cytokines TNF-α, IL-6, and IL-1β was decreased compared to the control group. As a result of observing H&E staining, lower crypt loss and inflammatory cell infiltration were found in the U. ohnoi oil group compared to the control group. Consequently, U. ohnoi oil appears to have great anti-inflammatory properties.
format	article
author	JeongEun Kang JiSun Park Jung-Kil Seo WonHyung Choi SooCheol Choi Ju-Hyoung Kim In-Ah Lee
author_facet	JeongEun Kang JiSun Park Jung-Kil Seo WonHyung Choi SooCheol Choi Ju-Hyoung Kim In-Ah Lee
author_sort	JeongEun Kang
title	Intestinal anti-inflammatory activity of Ulva ohnoi oil in DSS-induced experimental mouse model
title_short	Intestinal anti-inflammatory activity of Ulva ohnoi oil in DSS-induced experimental mouse model
title_full	Intestinal anti-inflammatory activity of Ulva ohnoi oil in DSS-induced experimental mouse model
title_fullStr	Intestinal anti-inflammatory activity of Ulva ohnoi oil in DSS-induced experimental mouse model
title_full_unstemmed	Intestinal anti-inflammatory activity of Ulva ohnoi oil in DSS-induced experimental mouse model
title_sort	intestinal anti-inflammatory activity of ulva ohnoi oil in dss-induced experimental mouse model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/816a5f988966469093a0b730449ffe0e
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Intestinal anti-inflammatory activity of Ulva ohnoi oil in DSS-induced experimental mouse model

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