Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure

Abstract An emerging concern is the influences of early life exposure to environmental toxicants on offspring characteristics in later life. Since recent evidence suggests a transgenerational transference of aberrant phenotypes from exposed-parents to non-exposed offspring related to adult-onset dis...

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Autores principales:	Lydia Enith Nava-Rivera, Nadia Denys Betancourt-Martínez, Rodrigo Lozoya-Martínez, Pilar Carranza-Rosales, Nancy Elena Guzmán-Delgado, Irma Edith Carranza-Torres, Hector Delgado-Aguirre, José Omar Zambrano-Ortíz, Javier Morán-Martínez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/816c36f2e5e143b2b716d6ca8abb6c0e
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spelling	oai:doaj.org-article:816c36f2e5e143b2b716d6ca8abb6c0e2021-12-02T18:02:48ZTransgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure10.1038/s41598-021-87677-y2045-2322https://doaj.org/article/816c36f2e5e143b2b716d6ca8abb6c0e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87677-yhttps://doaj.org/toc/2045-2322Abstract An emerging concern is the influences of early life exposure to environmental toxicants on offspring characteristics in later life. Since recent evidence suggests a transgenerational transference of aberrant phenotypes from exposed-parents to non-exposed offspring related to adult-onset diseases including reproductive phenotype. The transgenerational potential of arsenic a well know genotoxic and epigenetic modifier agent has not been assessed in mammals until now. In this experimental study, we evaluated the transgenerational effects of arsenic in a rat model with chronic exposure to arsenic. Rats chronically exposed to arsenic in drinking water (1 mg As2O3/mL) (F0) were mated to produce the arsenic lineage (F1, F2, and F3). The arsenic toxic effects on were evaluated over the four generations by analyzing the DNA methylation percentage, genotoxicity in WBC and physical and reproductive parameters, including sperm quality parameters and histopathological evaluation of the gonads. Chronic exposure to arsenic caused genotoxic damage (F0–F3) different methylation patterns, alterations in physical and reproductive parameters, aberrant morphology in the ovaries (F0 and F1) and testicles (F1–F3), and a decrease in the quality of sperm (F0–F3, except F2). Parental chronic arsenic exposure causes transgenerational genotoxicity and changes in global DNA methylation which might be associated with reproductive defects in rats. Combined with recent studies reveal that disturbances in the early life of an individual can affect the health of later generations.Lydia Enith Nava-RiveraNadia Denys Betancourt-MartínezRodrigo Lozoya-MartínezPilar Carranza-RosalesNancy Elena Guzmán-DelgadoIrma Edith Carranza-TorresHector Delgado-AguirreJosé Omar Zambrano-OrtízJavier Morán-MartínezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lydia Enith Nava-Rivera Nadia Denys Betancourt-Martínez Rodrigo Lozoya-Martínez Pilar Carranza-Rosales Nancy Elena Guzmán-Delgado Irma Edith Carranza-Torres Hector Delgado-Aguirre José Omar Zambrano-Ortíz Javier Morán-Martínez Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure
description	Abstract An emerging concern is the influences of early life exposure to environmental toxicants on offspring characteristics in later life. Since recent evidence suggests a transgenerational transference of aberrant phenotypes from exposed-parents to non-exposed offspring related to adult-onset diseases including reproductive phenotype. The transgenerational potential of arsenic a well know genotoxic and epigenetic modifier agent has not been assessed in mammals until now. In this experimental study, we evaluated the transgenerational effects of arsenic in a rat model with chronic exposure to arsenic. Rats chronically exposed to arsenic in drinking water (1 mg As2O3/mL) (F0) were mated to produce the arsenic lineage (F1, F2, and F3). The arsenic toxic effects on were evaluated over the four generations by analyzing the DNA methylation percentage, genotoxicity in WBC and physical and reproductive parameters, including sperm quality parameters and histopathological evaluation of the gonads. Chronic exposure to arsenic caused genotoxic damage (F0–F3) different methylation patterns, alterations in physical and reproductive parameters, aberrant morphology in the ovaries (F0 and F1) and testicles (F1–F3), and a decrease in the quality of sperm (F0–F3, except F2). Parental chronic arsenic exposure causes transgenerational genotoxicity and changes in global DNA methylation which might be associated with reproductive defects in rats. Combined with recent studies reveal that disturbances in the early life of an individual can affect the health of later generations.
format	article
author	Lydia Enith Nava-Rivera Nadia Denys Betancourt-Martínez Rodrigo Lozoya-Martínez Pilar Carranza-Rosales Nancy Elena Guzmán-Delgado Irma Edith Carranza-Torres Hector Delgado-Aguirre José Omar Zambrano-Ortíz Javier Morán-Martínez
author_facet	Lydia Enith Nava-Rivera Nadia Denys Betancourt-Martínez Rodrigo Lozoya-Martínez Pilar Carranza-Rosales Nancy Elena Guzmán-Delgado Irma Edith Carranza-Torres Hector Delgado-Aguirre José Omar Zambrano-Ortíz Javier Morán-Martínez
author_sort	Lydia Enith Nava-Rivera
title	Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure
title_short	Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure
title_full	Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure
title_fullStr	Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure
title_full_unstemmed	Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure
title_sort	transgenerational effects in dna methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/816c36f2e5e143b2b716d6ca8abb6c0e
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Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure

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