Conserved arginine residues in synaptotagmin 1 regulate fusion pore expansion through membrane contact
Synaptotagmin 1 (Syt1) is the calcium sensor for fast synchronous neurotransmitter release but the mechanism by which it functions is still under debate. Here, the authors combine EPR measurements and functional studies and observe that different faces of the Syt1 C2B domain play different roles in...
Enregistré dans:
Auteurs principaux: | Sarah B. Nyenhuis, Nakul Karandikar, Volker Kiessling, Alex J. B. Kreutzberger, Anusa Thapa, Binyong Liang, Lukas K. Tamm, David S. Cafiso |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/81777fc5abd14f21a6ee0ae5308e9f0f |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties
par: Alex J. B. Kreutzberger, et autres
Publié: (2019) -
Line tension at lipid phase boundaries as driving force for HIV fusion peptide-mediated fusion
par: Sung-Tae Yang, et autres
Publié: (2016) -
Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
par: Nicholas A. Courtney, et autres
Publié: (2019) -
Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin
par: Kirill Grushin, et autres
Publié: (2019) -
Different states of synaptotagmin regulate evoked versus spontaneous release
par: Hua Bai, et autres
Publié: (2016)